| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxanthine-guanine phosphoribosyltransferase |
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| Ligand | BDBM50467708 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1796653 (CHEMBL4268770) |
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| Ki | 130±n/a nM |
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| Citation |  Eng, WS; Rejman, D; Pohl, R; West, NP; Woods, K; Naesens, LMJ; Keough, DT; Guddat, LW Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase. Eur J Med Chem159:10-22 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxanthine-guanine phosphoribosyltransferase |
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| Name: | Hypoxanthine-guanine phosphoribosyltransferase |
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| Synonyms: | 2.4.2.8 | HGPRT | HGPRT_MYCTU | HGPRTase | Hypoxanthine-guanine phosphoribosyltransferase | hprT | hprT | hpt |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22244.35 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | ChEMBL_117829 |
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| Residue: | 202 |
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| Sequence: | MHVTQSSSAITPGQTAELYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLL
LITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIHGRDVLI
VEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYG
LDYDERYRDLSYIGTLDPRVYQ
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| BDBM50467708 |
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| n/a |
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| Name | BDBM50467708 |
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| Synonyms: | CHEMBL4277753 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H22N6O10P2 |
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| Mol. Mass. | 496.3062 |
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| SMILES | Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@H]1OC[C@H](O)P(O)(O)=O)C(=O)CCP(O)(O)=O |r| |
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| Structure | 
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