Compile Data Set for Download or QSAR

Found 184 hits with Last Name = 'pohl' and Initial = 'r'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50467705 (CHEMBL4282830) Show SMILES O[C@H](CO[C@@H]1CN(C[C@H]1n1cnc2c(O)ncnc12)C(=O)CCP(O)(O)=O)P(O)(O)=O |r| Show InChI InChI=1S/C14H21N5O10P2/c20-10(1-2-30(23,24)25)18-3-8(9(4-18)29-5-11(21)31(26,27)28)19-7-17-12-13(19)15-6-16-14(12)22/h6-9,11,21H,1-5H2,(H,15,16,22)(H2,23,24,25)(H2,26,27,28)/t8-,9-,11+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human HGPRT using fixed concentration of guanine and variable concentrations of PRib-PP as substrate by spectrophotometric analysis				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50467710 (CHEMBL4290716) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@H]1OC[C@@H](O)P(O)(O)=O)C(=O)CCP(O)(O)=O |r| Show InChI InChI=1S/C14H22N6O10P2/c15-14-17-12-11(13(23)18-14)16-6-20(12)7-3-19(9(21)1-2-31(24,25)26)4-8(7)30-5-10(22)32(27,28)29/h6-8,10,22H,1-5H2,(H2,24,25,26)(H2,27,28,29)(H3,15,17,18,23)/t7-,8-,10+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of recombinant human HGPRT using fixed concentration of guanine and variable concentrations of PRib-PP as substrate by Hanes plot analysis				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair				3D Structure (crystal)
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human DoHH2 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of human recombinant PNP using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50467708 (CHEMBL4277753) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@H]1OC[C@H](O)P(O)(O)=O)C(=O)CCP(O)(O)=O |r| Show InChI InChI=1S/C14H22N6O10P2/c15-14-17-12-11(13(23)18-14)16-6-20(12)7-3-19(9(21)1-2-31(24,25)26)4-8(7)30-5-10(22)32(27,28)29/h6-8,10,22H,1-5H2,(H2,24,25,26)(H2,27,28,29)(H3,15,17,18,23)/t7-,8-,10-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of recombinant human HGPRT using fixed concentration of guanine and variable concentrations of PRib-PP as substrate by Hanes plot analysis				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50467712 (CHEMBL4285691) Show SMILES O[C@@H](CO[C@@H]1CN(C[C@H]1n1cnc2c(O)ncnc12)C(=O)CCP(O)(O)=O)P(O)(O)=O |r| Show InChI InChI=1S/C14H21N5O10P2/c20-10(1-2-30(23,24)25)18-3-8(9(4-18)29-5-11(21)31(26,27)28)19-7-17-12-13(19)15-6-16-14(12)22/h6-9,11,21H,1-5H2,(H,15,16,22)(H2,23,24,25)(H2,26,27,28)/t8-,9-,11-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human HGPRT using fixed concentration of guanine and variable concentrations of PRib-PP as substrate by spectrophotometric analysis				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human Jurkat cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human K562 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human MINO cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human PBMC using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human MC116 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human SU-DHL-1 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human AML cells obtained from patients using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human CML cells obtained from patients using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human Jurkat cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human OPM2 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human HBL2 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20079 (5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...) Show SMILES Clc1c(CN2CCCC2=N)[nH]c(=O)[nH]c1=O Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Inhibition of human recombinant thymidine phosphorylase				Bioorg Med Chem Lett 20: 862-5 (2010) Article DOI: 10.1016/j.bmcl.2009.12.081 BindingDB Entry DOI: 10.7270/Q2930V4K
					More data for this Ligand-Target Pair				3D Structure (crystal)
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human PBMC using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human RPMI8226 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382672 (CHEMBL2024005) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human HBL2 tumor cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of human recombinant PNP using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human MINO cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50467707 (CHEMBL4280490) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1OCCP(O)(O)=O)C(=O)CCP(O)(O)=O |r| Show InChI InChI=1S/C14H22N6O9P2/c15-14-17-12-11(13(22)18-14)16-7-20(12)8-5-19(10(21)1-3-30(23,24)25)6-9(8)29-2-4-31(26,27)28/h7-9H,1-6H2,(H2,23,24,25)(H2,26,27,28)(H3,15,17,18,22)/t8-,9+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human HGPRT using fixed concentration of guanine and variable concentrations of PRib-PP as substrate by spectrophotometric analysis				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human SU-DHL-1 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50467707 (CHEMBL4280490) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1OCCP(O)(O)=O)C(=O)CCP(O)(O)=O |r| Show InChI InChI=1S/C14H22N6O9P2/c15-14-17-12-11(13(22)18-14)16-7-20(12)8-5-19(10(21)1-3-30(23,24)25)6-9(8)29-2-4-31(26,27)28/h7-9H,1-6H2,(H2,23,24,25)(H2,26,27,28)(H3,15,17,18,22)/t8-,9+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of Mycobacterium tuberculosis recombinant N-terminal 6His-tagged HGPRT expressed in Escherichia coli BL21 (DE3) using fixed concentration ...				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human DoHH2 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human RPMI8226 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human MC116 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human AML cells obtained from patients using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50467705 (CHEMBL4282830) Show SMILES O[C@H](CO[C@@H]1CN(C[C@H]1n1cnc2c(O)ncnc12)C(=O)CCP(O)(O)=O)P(O)(O)=O |r| Show InChI InChI=1S/C14H21N5O10P2/c20-10(1-2-30(23,24)25)18-3-8(9(4-18)29-5-11(21)31(26,27)28)19-7-17-12-13(19)15-6-16-14(12)22/h6-9,11,21H,1-5H2,(H,15,16,22)(H2,23,24,25)(H2,26,27,28)/t8-,9-,11+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of Mycobacterium tuberculosis recombinant N-terminal 6His-tagged HGPRT expressed in Escherichia coli BL21 (DE3) using fixed concentration ...				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human K562 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50467710 (CHEMBL4290716) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@H]1OC[C@@H](O)P(O)(O)=O)C(=O)CCP(O)(O)=O |r| Show InChI InChI=1S/C14H22N6O10P2/c15-14-17-12-11(13(23)18-14)16-6-20(12)7-3-19(9(21)1-2-31(24,25)26)4-8(7)30-5-10(22)32(27,28)29/h6-8,10,22H,1-5H2,(H2,24,25,26)(H2,27,28,29)(H3,15,17,18,23)/t7-,8-,10+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of Mycobacterium tuberculosis recombinant N-terminal 6His-tagged HGPRT expressed in Escherichia coli BL21 (DE3) using fixed concentration ...				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair				3D Structure (crystal)
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	77	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human CML cells obtained from patients using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	78	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human OPM2 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	98	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human HBL2 cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50382673 (CHEMBL2024003) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1CCN(C1)C(=O)P(O)(O)=O |r| Show InChI InChI=1S/C10H13N6O5P/c11-9-13-7-6(8(17)14-9)12-4-16(7)5-1-2-15(3-5)10(18)22(19,20)21/h4-5H,1-3H2,(H2,19,20,21)(H3,11,13,14,17)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Competitive inhibition of PNP in human HBL2 tumor cells using MSEG as substrate by Dixon-plot analysis				J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50467708 (CHEMBL4277753) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@H]1OC[C@H](O)P(O)(O)=O)C(=O)CCP(O)(O)=O |r| Show InChI InChI=1S/C14H22N6O10P2/c15-14-17-12-11(13(23)18-14)16-6-20(12)7-3-19(9(21)1-2-31(24,25)26)4-8(7)30-5-10(22)32(27,28)29/h6-8,10,22H,1-5H2,(H2,24,25,26)(H2,27,28,29)(H3,15,17,18,23)/t7-,8-,10-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of Mycobacterium tuberculosis recombinant N-terminal 6His-tagged HGPRT expressed in Escherichia coli BL21 (DE3) using fixed concentration ...				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50467712 (CHEMBL4285691) Show SMILES O[C@@H](CO[C@@H]1CN(C[C@H]1n1cnc2c(O)ncnc12)C(=O)CCP(O)(O)=O)P(O)(O)=O |r| Show InChI InChI=1S/C14H21N5O10P2/c20-10(1-2-30(23,24)25)18-3-8(9(4-18)29-5-11(21)31(26,27)28)19-7-17-12-13(19)15-6-16-14(12)22/h6-9,11,21H,1-5H2,(H,15,16,22)(H2,23,24,25)(H2,26,27,28)/t8-,9-,11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of Mycobacterium tuberculosis recombinant N-terminal 6His-tagged HGPRT expressed in Escherichia coli BL21 (DE3) using fixed concentration ...				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50504220 (CHEMBL4454497) Show SMILES Nc1nc2n(CC[S+]([O-])CCP([O-])([O-])=O)cnc2c(=O)[nH]1 Show InChI InChI=1S/C9H14N5O5PS.2Na/c10-9-12-7-6(8(15)13-9)11-5-14(7)1-3-21(19)4-2-20(16,17)18;;/h5H,1-4H2,(H2,16,17,18)(H3,10,12,13,15);;/q;2*+1/p-2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human HGPRT using Prib-PP as substrate by Hanes-plot based method				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111667 BindingDB Entry DOI: 10.7270/Q2JS9TPT
					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50310202 ((2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-...) Show SMILES Cc1cn(CCOCP(O)(O)=O)c(=O)[nH]c1=O Show InChI InChI=1S/C8H13N2O6P/c1-6-4-10(8(12)9-7(6)11)2-3-16-5-17(13,14)15/h4H,2-3,5H2,1H3,(H,9,11,12)(H2,13,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	236	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Inhibition of human recombinant thymidine phosphorylase				Bioorg Med Chem Lett 20: 862-5 (2010) Article DOI: 10.1016/j.bmcl.2009.12.081 BindingDB Entry DOI: 10.7270/Q2930V4K
					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50310203 (8-(5-bromo-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydro...) Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(Br)c(=O)n(CCCCCCCCP(O)(O)=O)c1=O |r| Show InChI InChI=1S/C17H28BrN2O9P/c18-11-9-20(16-14(23)13(22)12(10-21)29-16)17(25)19(15(11)24)7-5-3-1-2-4-6-8-30(26,27)28/h9,12-14,16,21-23H,1-8,10H2,(H2,26,27,28)/t12-,13-,14-,16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	236	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Inhibition of human recombinant thymidine phosphorylase				Bioorg Med Chem Lett 20: 862-5 (2010) Article DOI: 10.1016/j.bmcl.2009.12.081 BindingDB Entry DOI: 10.7270/Q2930V4K
					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50310200 ((1-hydroxy-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimi...) Show SMILES Cc1cn(CC(CO)OCP(O)(O)=O)c(=O)[nH]c1=O Show InChI InChI=1S/C9H15N2O7P/c1-6-2-11(9(14)10-8(6)13)3-7(4-12)18-5-19(15,16)17/h2,7,12H,3-5H2,1H3,(H,10,13,14)(H2,15,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	236	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Inhibition of human recombinant thymidine phosphorylase				Bioorg Med Chem Lett 20: 862-5 (2010) Article DOI: 10.1016/j.bmcl.2009.12.081 BindingDB Entry DOI: 10.7270/Q2930V4K
					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50310199 ((1-fluoro-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimid...) Show SMILES Cc1cn(CC(CF)OCP(O)(O)=O)c(=O)[nH]c1=O Show InChI InChI=1S/C9H14FN2O6P/c1-6-3-12(9(14)11-8(6)13)4-7(2-10)18-5-19(15,16)17/h3,7H,2,4-5H2,1H3,(H,11,13,14)(H2,15,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	236	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Inhibition of human recombinant thymidine phosphorylase				Bioorg Med Chem Lett 20: 862-5 (2010) Article DOI: 10.1016/j.bmcl.2009.12.081 BindingDB Entry DOI: 10.7270/Q2930V4K
					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50310201 ((1-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-...) Show SMILES CC(Cn1cc(C)c(=O)[nH]c1=O)OCP(O)(O)=O Show InChI InChI=1S/C9H15N2O6P/c1-6-3-11(9(13)10-8(6)12)4-7(2)17-5-18(14,15)16/h3,7H,4-5H2,1-2H3,(H,10,12,13)(H2,14,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	236	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Inhibition of human recombinant thymidine phosphorylase				Bioorg Med Chem Lett 20: 862-5 (2010) Article DOI: 10.1016/j.bmcl.2009.12.081 BindingDB Entry DOI: 10.7270/Q2930V4K
					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50201010 (((2R,3aR,4R,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-...) Show SMILES Cc1cn([C@@H]2O[C@H](CO)[C@H]3O[C@@H](CP(O)(O)=O)O[C@@H]23)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C12H17N2O9P/c1-5-2-14(12(17)13-10(5)16)11-9-8(6(3-15)21-11)22-7(23-9)4-24(18,19)20/h2,6-9,11,15H,3-4H2,1H3,(H,13,16,17)(H2,18,19,20)/t6-,7-,8-,9-,11-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	236	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic Curated by ChEMBL					Assay Description Inhibition of human recombinant thymidine phosphorylase				Bioorg Med Chem Lett 20: 862-5 (2010) Article DOI: 10.1016/j.bmcl.2009.12.081 BindingDB Entry DOI: 10.7270/Q2930V4K
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50504218 (CHEMBL4437088) Show SMILES Nc1nc2n(CCSCCP([O-])([O-])=O)cnc2c(=O)[nH]1 Show InChI InChI=1S/C9H14N5O4PS/c10-9-12-7-6(8(15)13-9)11-5-14(7)1-3-20-4-2-19(16,17)18/h5H,1-4H2,(H2,16,17,18)(H3,10,12,13,15)/p-2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human HGPRT using Prib-PP as substrate by Hanes-plot based method				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111667 BindingDB Entry DOI: 10.7270/Q2JS9TPT
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50467709 (CHEMBL4291117) Show SMILES Oc1ncnc2n(cnc12)[C@@H]1CN(C[C@@H]1OCCP(O)(O)=O)C(=O)CCP(O)(O)=O |r| Show InChI InChI=1S/C14H21N5O9P2/c20-11(1-3-29(22,23)24)18-5-9(10(6-18)28-2-4-30(25,26)27)19-8-17-12-13(19)15-7-16-14(12)21/h7-10H,1-6H2,(H,15,16,21)(H2,22,23,24)(H2,25,26,27)/t9-,10+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of Mycobacterium tuberculosis recombinant N-terminal 6His-tagged HGPRT expressed in Escherichia coli BL21 (DE3) using fixed concentration ...				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50467709 (CHEMBL4291117) Show SMILES Oc1ncnc2n(cnc12)[C@@H]1CN(C[C@@H]1OCCP(O)(O)=O)C(=O)CCP(O)(O)=O |r| Show InChI InChI=1S/C14H21N5O9P2/c20-11(1-3-29(22,23)24)18-5-9(10(6-18)28-2-4-30(25,26)27)19-8-17-12-13(19)15-7-16-14(12)21/h7-10H,1-6H2,(H,15,16,21)(H2,22,23,24)(H2,25,26,27)/t9-,10+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human HGPRT using fixed concentration of guanine and variable concentrations of PRib-PP as substrate by spectrophotometric analysis				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50467711 (CHEMBL4283940) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CNC[C@@H]1OCP(O)(O)=O |r| Show InChI InChI=1S/C10H15N6O5P/c11-10-14-8-7(9(17)15-10)13-3-16(8)5-1-12-2-6(5)21-4-22(18,19)20/h3,5-6,12H,1-2,4H2,(H2,18,19,20)(H3,11,14,15,17)/t5-,6+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	740	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of Mycobacterium tuberculosis recombinant N-terminal 6His-tagged HGPRT expressed in Escherichia coli BL21 (DE3) using fixed concentration ...				Eur J Med Chem 159: 10-22 (2018) Article DOI: 10.1016/j.ejmech.2018.09.039 BindingDB Entry DOI: 10.7270/Q2D22197
					More data for this Ligand-Target Pair				3D Structure (crystal)

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