| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine phosphorylase |
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| Ligand | BDBM50201010 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_607911 (CHEMBL1066239) |
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| Ki | 236±n/a nM |
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| Citation |  Kocalka, P; Rejman, D; Vanek, V; Rinnová, M; Tomecková, I; Králíková, S; Petrová, M; Páv, O; Pohl, R; Budesínský, M; Liboska, R; Tocík, Z; Panova, N; Votruba, I; Rosenberg, I Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase. Bioorg Med Chem Lett20:862-5 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine phosphorylase |
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| Name: | Thymidine phosphorylase |
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| Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 49948.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
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| Residue: | 482 |
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| Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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| BDBM50201010 |
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| n/a |
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| Name | BDBM50201010 |
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| Synonyms: | ((2R,3aR,4R,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuro[3,4-d][1,3]dioxol-2-yl)methylphosphonic acid | ((2R,3aR,4R,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuro[3,4-d][1,3]dioxol-2-yl)methylphosphonic acid | CHEMBL374140 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H17N2O9P |
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| Mol. Mass. | 364.2451 |
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| SMILES | Cc1cn([C@@H]2O[C@H](CO)[C@H]3O[C@@H](CP(O)(O)=O)O[C@@H]23)c(=O)[nH]c1=O |r| |
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| Structure | 
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