Found 17 hits Enz. Inhib. hit(s) with Target = 'Thymidine phosphorylase' and Ligand = 'BDBM20079' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| 1.30 | -52.8 | n/a | n/a | n/a | n/a | n/a | 6.4 | 37 |
Gilead Sciences Inc.
| Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b... |
J Med Chem 50: 6016-23 (2007)
Article DOI: 10.1021/jm070644i BindingDB Entry DOI: 10.7270/Q2M043PX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic
Curated by ChEMBL
| Assay Description Inhibition of human recombinant thymidine phosphorylase |
Bioorg Med Chem Lett 20: 862-5 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.081 BindingDB Entry DOI: 10.7270/Q2930V4K |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Manchester
Curated by ChEMBL
| Assay Description Inhibition of human recombinant thymidine phosphorylase by [3H]thymidine incorporation assay |
Eur J Med Chem 43: 1248-60 (2008)
Article DOI: 10.1016/j.ejmech.2007.07.015 BindingDB Entry DOI: 10.7270/Q2Z31ZDP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description Inhibitory activity against thymidine phosphorylase |
J Med Chem 48: 392-402 (2005)
Article DOI: 10.1021/jm049494r BindingDB Entry DOI: 10.7270/Q2445N8K |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase |
J Med Chem 46: 207-9 (2003)
Article DOI: 10.1021/jm020964w BindingDB Entry DOI: 10.7270/Q24X574R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Escherichia coli) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description Inhibition of Thymidine phosphorylase from Escherichia coli |
Bioorg Med Chem Lett 14: 5247-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.036 BindingDB Entry DOI: 10.7270/Q2PR7VGP |
More data for this Ligand-Target Pair | |
Thymidine phosphorylase
(Escherichia coli) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description Inhibitory concentration against thymidine phosphorylase of Escherichia coli |
J Med Chem 48: 392-402 (2005)
Article DOI: 10.1021/jm049494r BindingDB Entry DOI: 10.7270/Q2445N8K |
More data for this Ligand-Target Pair | |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description Inhibitory concentration against human thymidine phosphorylase |
J Med Chem 48: 392-402 (2005)
Article DOI: 10.1021/jm049494r BindingDB Entry DOI: 10.7270/Q2445N8K |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Yunnan University
Curated by ChEMBL
| Assay Description Inhibition of thymidine phosphorylase (unknown origin) using thymidine as substrate after 1 hr by spectrophotometric analysis |
Eur J Med Chem 144: 41-51 (2018)
Article DOI: 10.1016/j.ejmech.2017.12.016 BindingDB Entry DOI: 10.7270/Q24M9762 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Yunnan University
Curated by ChEMBL
| Assay Description Inhibition of human placental thymidine phosphorylase using [6-3H]dThd as substrate after 5 mins by scintillation counting analysis |
Eur J Med Chem 144: 41-51 (2018)
Article DOI: 10.1016/j.ejmech.2017.12.016 BindingDB Entry DOI: 10.7270/Q24M9762 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Imam Abdulrahman Bin Faisal University
Curated by ChEMBL
| Assay Description Inhibition of human placenta thymidine phosphorylase using [6-3H]dThd as substrate after 5 mins by scintillation counting method |
Bioorg Med Chem 26: 3654-3663 (2018)
Article DOI: 10.1016/j.bmc.2018.05.046 BindingDB Entry DOI: 10.7270/Q22V2JKV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
AIMST University
Curated by ChEMBL
| Assay Description Inhibition of human placenta thymidine phosphorylase using [6-3H]dThd as substrate after 5 mins by scintillation counting method |
Eur J Med Chem 124: 992-1003 (2016)
Article DOI: 10.1016/j.ejmech.2016.10.032 BindingDB Entry DOI: 10.7270/Q2RR218S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
National University of Singapore
Curated by ChEMBL
| Assay Description Inhibition of human thymidine phosphorylase |
Eur J Med Chem 65: 1-11 (2013)
Article DOI: 10.1016/j.ejmech.2013.03.063 BindingDB Entry DOI: 10.7270/Q2125V2R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Escherichia coli) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Karachi
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli thymidine phosphorylase |
Bioorg Med Chem 17: 2983-8 (2009)
Article DOI: 10.1016/j.bmc.2009.03.020 BindingDB Entry DOI: 10.7270/Q2GX4FC3 |
More data for this Ligand-Target Pair | |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Manchester
Curated by ChEMBL
| Assay Description Inhibition of human recombinant thymidine phosphorylase by [3H]thymidine incorporation assay |
Eur J Med Chem 43: 1248-60 (2008)
Article DOI: 10.1016/j.ejmech.2007.07.015 BindingDB Entry DOI: 10.7270/Q2Z31ZDP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Homo sapiens (Human)) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
National University of Singapore
Curated by ChEMBL
| Assay Description Competitive inhibition of human thymidine phosphorylase in presence of thymidine |
Eur J Med Chem 70: 400-10 (2013)
Article DOI: 10.1016/j.ejmech.2013.10.022 BindingDB Entry DOI: 10.7270/Q2CZ38NN |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thymidine phosphorylase
(Escherichia coli) | BDBM20079
(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)Show InChI InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16) | PDB MMDB
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| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli Thymidine phosphorylase by spectrophotometry |
Eur J Med Chem 46: 1165-71 (2011)
Article DOI: 10.1016/j.ejmech.2011.01.035 BindingDB Entry DOI: 10.7270/Q2BP05MR |
More data for this Ligand-Target Pair | |