| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Ligand | BDBM50467979 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1797481 (CHEMBL4269598) |
|---|
| IC50 | 2.5±n/a nM |
|---|
| Citation |  Haile, PA; Casillas, LN; Bury, MJ; Mehlmann, JF; Singhaus, R; Charnley, AK; Hughes, TV; DeMartino, MP; Wang, GZ; Romano, JJ; Dong, X; Plotnikov, NV; Lakdawala, AS; Convery, MA; Votta, BJ; Lipshutz, DB; Desai, BM; Swift, B; Capriotti, CA; Berger, SB; Mahajan, MK; Reilly, MA; Rivera, EJ; Sun, HH; Nagilla, R; LePage, C; Ouellette, MT; Totoritis, RD; Donovan, BT; Brown, BS; Chaudhary, KW; Gough, PJ; Bertin, J; Marquis, RW Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel. ACS Med Chem Lett9:1039-1044 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Name: | Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Synonyms: | CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 61201.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 540 |
|---|
| Sequence: | MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
|
|
|
|---|
| BDBM50467979 |
|---|
| n/a |
|---|
| Name | BDBM50467979 |
|---|
| Synonyms: | CHEMBL4285837 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H26N4O2S |
|---|
| Mol. Mass. | 386.511 |
|---|
| SMILES | CCc1cc2nccc(Nc3n[nH]c(C)c3C)c2cc1S(=O)(=O)C(C)(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
