| Reaction Details |
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 | Report a problem with these data |
| Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Ligand | BDBM50024971 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_80665 |
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| IC50 | 890±n/a nM |
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| Citation |  Stokker, GE; Hoffman, WF; Alberts, AW; Cragoe, EJ; Deana, AA; Gilfillan, JL; Huff, JW; Novello, FC; Prugh, JD; Smith, RL 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives. J Med Chem28:347-58 (1985) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Synonyms: | HMDH_RAT | HMG-CoA reductase | Hmgcr |
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| Type: | Enzyme |
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| Mol. Mass.: | 96689.85 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Isolated rat liver microsomes were used as enzyme source. |
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| Residue: | 887 |
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| Sequence: | MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAEQSKVSLGLAEDVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVT
PKKAQDNCCRREPLLVRRNQKLSSVEEDPGVNQDRKVEVIKPLVAEAETSGRATFVLGAS
AASPPLALGAQEPGIELPSEPRPNEECLQILESAEKGAKFLSDAEIIQLVNAKHIPAYKL
ETLMETHERGVSIRRQLLSAKLAEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVA
GPLCLDGKEYQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMSRGPVVRLPRACD
SAEVKSWLETPEGFAVVKEAFDSTSRFARLQKLHVTLAGRNLYIRLQSKTGDAMGMNMIS
KGTEKALLKLQEFFPELQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVL
KTTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLM
EASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARI
VCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQGTCTKKAA
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| BDBM50024971 |
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| n/a |
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| Name | BDBM50024971 |
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| Synonyms: | 6-Fluoren-9-ylidenemethyl-4-hydroxy-tetrahydro-pyran-2-one | CHEMBL2367922 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16O3 |
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| Mol. Mass. | 292.3285 |
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| SMILES | [#8]-[#6@@H]-1-[#6]-[#6@H](-[#8]-[#6](=O)-[#6]-1)\[#6]=[#6]-1/c2ccccc2-c2ccccc-12 |
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| Structure | 
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