| Reaction Details |
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 | Report a problem with these data |
| Target | Ectonucleoside triphosphate diphosphohydrolase 1 |
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| Ligand | BDBM50468629 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1800816 (CHEMBL4273108) |
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| IC50 | 10100±n/a nM |
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| Citation |  Channar, PA; Afzal, S; Ejaz, SA; Saeed, A; Larik, FA; Mahesar, PA; Lecka, J; Sévigny, J; Erben, MF; Iqbal, J Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile. Eur J Med Chem156:461-478 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ectonucleoside triphosphate diphosphohydrolase 1 |
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| Name: | Ectonucleoside triphosphate diphosphohydrolase 1 |
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| Synonyms: | ATPDase | CD_antigen=CD39 | Cd39 | ENTP1_RAT | Ecto-ATP diphosphohydrolase | Ecto-apyrase | Entpd1 | Lymphoid cell activation antigen | NTPDase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57412.31 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_463990 |
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| Residue: | 511 |
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| Sequence: | MEDIKDSKVKRFCSKNILIILGFSSVLAVIALIAVGLTHNKPLPENVKYGIVLDAGSSHT
NLYIYKWPAEKENDTGVVQLLEECQVKGPGISKYAQKTDEIAAYLAECMKMSTERIPASK
QHQTPVYLGATAGMRLLRMESKQSADEVLAAVSRSLKSYPFDFQGAKIITGQEEGAYGWI
TINYLLGRFTQEQSWLNFISDSQKQATFGALDLGGSSTQVTFVPLNQTLEAPETSLQFRL
YGTDYTVYTHSFLCYGKDQALWQKLAQDIQVSSGGILKDPCFYPGYKKVVNVSELYGTPC
TKRFEKKLPFNQFQVQGTGDYEQCHQSILKFFNNSHCPYSQCAFNGVFLPPLQGSFGAFS
AFYFVMDFFKKMANDSVSSQEKMTEITKNFCSKPWEEVKASYPTVKEKYLSEYCFSGTYI
LSLLLQGYNFTGTSWDQIHFMGKIKDSNAGWTLGYMLNLTNMIPAEQPLSPPLPHSTYIS
LMVLFSLVLVAMVITGLFIFSKPSYFWKEAV
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| BDBM50468629 |
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| n/a |
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| Name | BDBM50468629 |
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| Synonyms: | CHEMBL4279910 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12N2O2 |
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| Mol. Mass. | 216.2359 |
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| SMILES | Cc1cc(=O)n([nH]1)C(=O)c1ccc(C)cc1 |
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| Structure | 
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