Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Fyn | ||
| Ligand | BDBM8793 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1802631 (CHEMBL4274923) | ||
| IC50 | 0.300000±n/a nM | ||
| Citation |  Pathania, S; Rawal, RK Pyrrolopyrimidines: An update on recent advancements in their medicinal attributes. Eur J Med Chem157:503-526 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Fyn | |||
| Name: | Tyrosine-protein kinase Fyn | ||
| Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 60762.21 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P06241 | ||
| Residue: | 537 | ||
| Sequence: |
| ||
| BDBM8793 | |||
| n/a | |||
| Name | BDBM8793 | ||
| Synonyms: | 7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | CHEMBL45177 | Pyrrolo[2,3-d]pyrimidine 1 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H34N6O | ||
| Mol. Mass. | 482.6199 | ||
| SMILES | CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12 |r,wU:10.14,wD:7.7,(-.91,-10.51,;-1.37,-9.04,;-2.87,-8.71,;-3.34,-7.24,;-2.3,-6.11,;-.8,-6.44,;-.33,-7.91,;-2.72,-4.63,;-1.64,-3.52,;-2.06,-2.04,;-3.55,-1.66,;-4.63,-2.76,;-4.21,-4.25,;-4.03,-.2,;-3.12,1.05,;-4.03,2.3,;-3.55,3.76,;-4.69,4.8,;-4.36,6.3,;-2.89,6.77,;-2.56,8.27,;-1.1,8.74,;-.48,10.15,;1.05,10.33,;1.96,9.09,;1.35,7.68,;-.18,7.5,;-1.75,5.73,;-2.08,4.23,;-5.49,1.82,;-6.82,2.59,;-6.82,4.13,;-8.16,1.82,;-8.16,.28,;-6.82,-.49,;-5.49,.28,)| | ||
| Structure | 
| ||