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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | NUAK family SNF1-like kinase 1 | ||
| Ligand | BDBM50055496 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1804069 (CHEMBL4276361) | ||
| IC50 | 8.0±n/a nM | ||
| Citation |  Zhao, J; Zhang, D; Zhang, W; Stashko, MA; DeRyckere, D; Vasileiadi, E; Parker, RE; Hunter, D; Liu, Q; Zhang, Y; Norris-Drouin, J; Li, B; Drewry, DH; Kireev, D; Graham, DK; Earp, HS; Frye, SV; Wang, X Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. J Med Chem61:10242-10254 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| NUAK family SNF1-like kinase 1 | |||
| Name: | NUAK family SNF1-like kinase 1 | ||
| Synonyms: | ARK5 | KIAA0537 | NUAK1 | NUAK1_HUMAN | OMPHK1 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 74326.51 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1451343 | ||
| Residue: | 661 | ||
| Sequence: |
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| BDBM50055496 | |||
| n/a | |||
| Name | BDBM50055496 | ||
| Synonyms: | CHEMBL3326006 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H40N6O | ||
| Mol. Mass. | 476.6568 | ||
| SMILES | CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1 |r,wU:12.11,wD:15.15,(14.5,-10.38,;14.49,-11.92,;15.83,-12.69,;17.16,-11.92,;18.49,-12.69,;19.83,-11.92,;19.83,-10.38,;21.16,-9.61,;22.49,-10.37,;23.97,-9.89,;24.88,-11.15,;23.97,-12.4,;24.44,-13.87,;25.95,-14.19,;26.42,-15.66,;25.39,-16.8,;25.86,-18.27,;23.88,-16.47,;23.41,-15.02,;22.49,-11.92,;21.16,-12.69,;24.45,-8.43,;25.96,-8.11,;26.43,-6.65,;25.41,-5.5,;25.89,-4.03,;27.4,-3.74,;28.41,-4.9,;29.91,-4.6,;30.41,-3.14,;31.92,-2.84,;29.4,-1.99,;27.88,-2.28,;23.9,-5.82,;23.42,-7.29,)| | ||
| Structure | 
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