| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
|---|
| Ligand | BDBM50470289 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_204599 (CHEMBL813361) |
|---|
| IC50 | 7.2±n/a nM |
|---|
| Citation |  Kumazawa, T; Takami, H; Kishibayashi, N; Ishii, A; Nagahara, Y; Hirayama, N; Obase, H (E)-4-(2-[[3-(indol-5-yl)-1-oxo-2-butenyl]amino]phenoxy)butyric acid derivatives: a new class of steroid 5 alpha-reductase inhibitors in the rat prostate. 1. J Med Chem38:2887-92 (1995) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
|---|
| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
|---|
| Synonyms: | Steroid 5-alpha-reductase |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 204723 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
|---|
| Synonyms: | S5A1_RAT | Srd5a1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 29788.29 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1441437 |
|---|
| Residue: | 259 |
|---|
| Sequence: | MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQE
LPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLA
FLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGE
TGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWY
HEKFEDYPKSRKILIPFVL
|
|
|
|---|
| Component 2 |
| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
|---|
| Synonyms: | S5A2_RAT | Srd5a2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 28784.15 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_205054 |
|---|
| Residue: | 254 |
|---|
| Sequence: | MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPS
FVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCI
GNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRI
PRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFK
DYPKSRKALIPFIF
|
|
|
|---|
| BDBM50470289 |
|---|
| n/a |
|---|
| Name | BDBM50470289 |
|---|
| Synonyms: | CHEMBL96030 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H36N2O4 |
|---|
| Mol. Mass. | 476.6071 |
|---|
| SMILES | CCCC(C(C)C)n1ccc2cc(ccc12)C(\C)=C\C(=O)Nc1ccccc1OCCCC(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
