| Reaction Details |
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 | Report a problem with these data |
| Target | Isoleucine--tRNA ligase |
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| Ligand | BDBM50470915 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_88818 (CHEMBL698873) |
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| IC50 | 835000±n/a nM |
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| Citation |  Broom, NJ; Cassels, R; Cheng, HY; Elder, JS; Hannan, PC; Masson, N; O'Hanlon, PJ; Pope, A; Wilson, JM The chemistry of pseudomonic acid. 17. Dual-action C-1 oxazole derivatives of pseudomonic acid having an extended spectrum of antibacterial activity. J Med Chem39:3596-600 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoleucine--tRNA ligase |
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| Name: | Isoleucine--tRNA ligase |
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| Synonyms: | IleRS | Isoleucine--tRNA ligase | Isoleucyl-tRNA synthetase | SYI1_STAAU | ileS |
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| Type: | PROTEIN |
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| Mol. Mass.: | 104861.59 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_88808 |
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| Residue: | 917 |
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| Sequence: | MDYKETLLMPKTDFPMRGGLPNKEPQIQEKWDAEDQYHKALEKNKGNETFILHDGPPYAN
GNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRKKMSTAEF
REKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGK
KPVYWSPSSESSLAEAEIEYHDKRSASIYVAFNVKDDKGVVDADAKFIIWTTTPWTIPSN
VAITVHPELKYGQYNVNGEKYIIAEALSDAVAEALDWDKASIKLEKEYTGKELEYVVAQH
PFLDRESLVINGDHVTTDAGTGCVHTAPGHGEDDYIVGQKYELPVISPIDDKGVFTEEGG
QFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISKVR
QDILDAIENTNFKVNWGKTRIYNMVRDRGEWVISRQRVWGVPLPVFYAENGEIIMTKETV
NHVADLFAEHGSNIWFEREAKDLLPEGFTHPGSPNGTFTKETDIMDVWFDSGSSHRGVLE
TRPELSFPADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSL
GNVIVPDQVVKQKGADIARLWVSSTDYLADVRISDEILKQTSDVYRKIRNTLRFMLGNIN
DFNPDTDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINVELSNFY
LDYGKDILYIEQRDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSHTPHVKEESVH
LADMPKVVEVDQALLDKWRTFMNLRDDVNRALETARNEKVIGKSLEAKVTIASNDKFNAS
EFLTSFDALHQLFIVSQVKVVDKLDDQATAYEHGDIVIEHADGEKCERCWNYSEDLGAVD
ELTHLCPRCQQVVKSLV
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| BDBM50470915 |
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| n/a |
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| Name | BDBM50470915 |
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| Synonyms: | CHEMBL118698 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N2O9 |
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| Mol. Mass. | 478.4923 |
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| SMILES | [H][C@]1(O[C@H]1C[C@H]1CO[C@@H](C\C(C)=C\c2ncc(o2)-c2ccc(o2)[N+]([O-])=O)[C@H](O)[C@@H]1O)[C@@H](C)[C@H](C)O |
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| Structure | 
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