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TargetType-1 angiotensin II receptor A/B
LigandBDBM50472359
Substrate/Competitorn/a
Meas. Tech.ChEMBL_35113 (CHEMBL649315)
Ki 750±n/a nM
Citation Johannesson, P; Lindeberg, G; Tong, W; Gogoll, A; Synnergren, B; Nyberg, F; Karlén, A; Hallberg, A Angiotensin II analogues encompassing 5,9- and 5,10-fused thiazabicycloalkane tripeptide mimetics. J Med Chem42:4524-37 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Type-1 angiotensin II receptor A/B
Name:Type-1 angiotensin II receptor A/B
Synonyms:Angiotensin II receptor (AT-1) type-1 | Type-1A/Type-1B angiotensin II receptor
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 901964
Components:This complex has 2 components.
Component 1
Name:Type-1 angiotensin II receptor B
Synonyms:AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:40929.44
Organism:RAT
Description:Angiotensin II AT1B 0 RAT::P29089
Residue:359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
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Component 2
Name:Type-1 angiotensin II receptor A
Synonyms:AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:40910.53
Organism:RAT
Description:ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
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BDBM50472359
n/a
NameBDBM50472359
Synonyms:CHEMBL411733
TypeSmall organic molecule
Emp. Form.C48H63N13O12S
Mol. Mass.1046.159
SMILES[H][C@]12CC[C@H](N1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCS2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O |wU:60.65,47.49,27.37,8.9,1.0,wD:4.46,20.26,64.68,38.41,(11.31,-12.86,;10.64,-11.11,;11.95,-11.95,;13.14,-10.97,;12.56,-9.53,;11.02,-9.62,;10.62,-8.13,;11.7,-7.03,;9.52,-7.03,;10.01,-5.56,;11.09,-4.46,;12.6,-4.86,;13.67,-3.76,;13.28,-2.26,;14.35,-1.17,;11.76,-1.87,;10.67,-2.99,;7.79,-7.29,;7.05,-8.63,;5.55,-8.24,;7.05,-10.18,;7.44,-11.65,;8.73,-12.98,;10.23,-12.61,;5.72,-9.41,;4.39,-10.18,;4.39,-11.72,;3.06,-9.41,;3.06,-7.87,;4.39,-7.1,;4.39,-5.56,;5.72,-4.79,;5.72,-3.25,;7.05,-2.48,;4.39,-2.48,;1.71,-10.18,;.38,-9.41,;.38,-7.87,;-.95,-10.18,;-2.29,-9.41,;-.95,-11.72,;-2.29,-12.49,;-3.62,-11.72,;-2.29,-14.03,;13.89,-8.75,;13.88,-7.21,;15.24,-9.5,;16.55,-8.73,;16.54,-7.19,;17.87,-6.4,;19.4,-6.4,;19.89,-4.93,;18.64,-4.02,;17.39,-4.93,;17.9,-9.48,;17.9,-11.02,;19.23,-8.7,;18.74,-7.23,;19.98,-6.33,;21.24,-7.23,;20.77,-8.7,;22.1,-9.47,;22.1,-11.01,;23.43,-8.69,;24.76,-9.46,;24.78,-11,;25.53,-12.33,;27.05,-12.33,;27.82,-13.65,;27.05,-14.98,;25.51,-14.96,;24.76,-13.65,;26.09,-8.68,;27.42,-9.43,;26.09,-7.14,)|
Structure
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