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TargetType-1 angiotensin II receptor A/B
LigandBDBM50472361
Substrate/Competitorn/a
Meas. Tech.ChEMBL_35113 (CHEMBL649315)
Ki 0.190000±n/a nM
Citation Johannesson, P; Lindeberg, G; Tong, W; Gogoll, A; Synnergren, B; Nyberg, F; Karlén, A; Hallberg, A Angiotensin II analogues encompassing 5,9- and 5,10-fused thiazabicycloalkane tripeptide mimetics. J Med Chem42:4524-37 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Type-1 angiotensin II receptor A/B
Name:Type-1 angiotensin II receptor A/B
Synonyms:Angiotensin II receptor (AT-1) type-1 | Type-1A/Type-1B angiotensin II receptor
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 901964
Components:This complex has 2 components.
Component 1
Name:Type-1 angiotensin II receptor B
Synonyms:AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:40929.44
Organism:RAT
Description:Angiotensin II AT1B 0 RAT::P29089
Residue:359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
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Component 2
Name:Type-1 angiotensin II receptor A
Synonyms:AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:40910.53
Organism:RAT
Description:ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
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BDBM50472361
n/a
NameBDBM50472361
Synonyms:CHEMBL406349
TypeSmall organic molecule
Emp. Form.C47H63N13O12S2
Mol. Mass.1066.213
SMILESN[C@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CCSSCC[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O)C(=O)N[C@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(O)=O |wU:59.63,46.47,9.8,31.31,wD:20.19,27.44,63.66,1.0,(-2.49,-6.28,;-2.47,-4.62,;-3.84,-3.93,;-5.11,-4.77,;-5.13,-6.21,;-6.53,-4.07,;-1.11,-3.93,;-1.11,-2.41,;.19,-4.74,;1.56,-4.01,;1.59,-2.47,;2.96,-1.73,;2.99,-.19,;4.35,.53,;4.39,2.07,;5.75,2.8,;3.09,2.89,;2.87,-4.81,;2.68,-3.3,;4.21,-5.54,;5.55,-4.77,;5.54,-3.23,;6.63,-2.13,;7.96,-1.36,;11.63,-.89,;13.17,-.89,;14.26,-1.99,;13.54,-3.36,;12.02,-3.43,;10.48,-3.48,;9.64,-2.18,;9.76,-4.85,;10.66,-6.02,;9.85,-7.26,;10.53,-8.56,;9.71,-9.78,;8.24,-9.71,;7.43,-10.95,;7.57,-8.41,;8.36,-7.17,;8.22,-4.77,;6.89,-5.54,;6.89,-7.08,;14.37,-4.67,;14.36,-6.19,;15.85,-4.25,;17.23,-4.78,;17.41,-6.19,;16.4,-7.33,;15.13,-6.82,;14.1,-7.96,;14.75,-9.19,;16.19,-8.82,;18.23,-3.64,;17.74,-2.18,;19.74,-3.95,;19.74,-2.41,;21.22,-1.94,;22.12,-3.13,;21.21,-4.39,;21.7,-5.86,;20.68,-7.01,;23.2,-6.16,;24.74,-6.17,;25.76,-4.98,;24.97,-3.64,;23.43,-3.64,;22.64,-2.29,;23.43,-.94,;24.97,-.94,;25.76,-2.29,;25.25,-7.63,;24.37,-8.87,;26.67,-7.65,)|
Structure
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