Ki Summary

Reaction Details

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Target

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

Ligand

BDBM50472814

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_152460 (CHEMBL761449)

IC50

4160±n/a nM

Citation

Aicher, TD; Anderson, RC; Gao, J; Shetty, SS; Coppola, GM; Stanton, JL; Knorr, DC; Sperbeck, DM; Brand, LJ; Vinluan, CC; Kaplan, EL; Dragland, CJ; Tomaselli, HC; Islam, A; Lozito, RJ; Liu, X; Maniara, WM; Fillers, WS; DelGrande, D; Walter, RE; Mann, WR Secondary amides of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase. J Med Chem43:236-49 (2000) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

Name:

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

Synonyms:

2.7.11.2 | PDK4_RAT | Pdk4 | Pyruvate dehydrogenase kinase isoform 4 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

Type:

PROTEIN

Mol. Mass.:

46681.07

Organism:

Rattus norvegicus

Description:

ChEMBL_104818

Residue:

412

Sequence:

MKAARFVMRSASSLGNAGLVPREVELFSRYSPSPLSMKQLLDFGSENACERTSFSFLRQE
LPVRLANILKEIDILPEHLVNTPSVQLVKSWYIQSLMDLVEFHEKSPEDQKVLSDFVDTL
VKVRNRHHNVVPTMAQGILEYKDNCTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIF
SDSKTGNPSHIGSIDPNCDVVAVVEDAFECAKMLCDQYYLTSPELKLTQVNGKFPGQPIH
IVYVPSHLHHMLFELFKNAMRATVEHQENRPFLTPVEATVVLGKEDLTIKISDRGGGVPL
RITDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDA
IIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSKEPKNLSKEKLAV

BDBM50472814

n/a

Name

BDBM50472814

Synonyms:

CHEMBL309318

Type

Small organic molecule

Emp. Form.

C14H17F3N2O2

Mol. Mass.

302.2922

SMILES

C[C@@](O)(C(=O)N1CCN(CC1)c1ccccc1)C(F)(F)F

Structure