Ki Summary

Reaction Details

Report a problem with these data

Target

5-hydroxytryptamine receptor 1D

Ligand

BDBM50473508

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1743 (CHEMBL616948)

IC50

15±n/a nM

Citation

Jandu, KS; Barrett, V; Brockwell, M; Cambridge, D; Farrant, DR; Foster, C; Giles, H; Glen, RC; Hill, AP; Hobbs, H; Honey, A; Martin, GR; Salmon, J; Smith, D; Woollard, P; Selwood, DL Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem44:681-93 (2001) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1D

Name:

5-hydroxytryptamine receptor 1D

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

41920.63

Organism:

Homo sapiens (Human)

Description:

Receptor binding assays were performed using human clone stably expressed in CHO cells.

Residue:

377

Sequence:

MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL
TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT
CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK
AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT
TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT
KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN
EEFRQAFQKIVPFRKAS

BDBM50473508

n/a

Name

BDBM50473508

Synonyms:

CHEMBL158638

Type

Small organic molecule

Emp. Form.

C15H19N3O

Mol. Mass.

257.3309

SMILES

CN(C)[C@H]1C[C@@H](C1)c1c[nH]c2ccc(cc12)C(N)=O |wU:5.7,wD:3.2,(14.61,-11.78,;15.62,-10.62,;17.13,-10.94,;15.14,-9.17,;15.83,-7.79,;14.45,-7.1,;13.77,-8.47,;13.98,-5.65,;14.87,-4.39,;13.96,-3.15,;12.49,-3.64,;11.16,-2.87,;9.83,-3.64,;9.83,-5.18,;11.16,-5.95,;12.51,-5.18,;8.49,-5.95,;8.49,-7.47,;7.16,-5.18,)|

Structure