Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1D

Ligand

BDBM50473516

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1743 (CHEMBL616948)

IC50

3.6±n/a nM

Citation

Jandu, KS; Barrett, V; Brockwell, M; Cambridge, D; Farrant, DR; Foster, C; Giles, H; Glen, RC; Hill, AP; Hobbs, H; Honey, A; Martin, GR; Salmon, J; Smith, D; Woollard, P; Selwood, DL Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem44:681-93 (2001) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1D

Name:

5-hydroxytryptamine receptor 1D

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

41920.63

Organism:

Homo sapiens (Human)

Description:

Receptor binding assays were performed using human clone stably expressed in CHO cells.

Residue:

377

Sequence:

MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL
TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT
CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK
AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT
TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT
KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN
EEFRQAFQKIVPFRKAS

BDBM50473516

n/a

Name

BDBM50473516

Synonyms:

CHEMBL2110299

Type

Small organic molecule

Emp. Form.

C16H19N3O2

Mol. Mass.

285.341

SMILES

N[C@H]1C[C@@H](C1)c1c[nH]c2ccc(CC3COC(=O)N3)cc12 |wU:1.0,wD:3.5,(17.46,-8.49,;16.99,-7.03,;15.61,-6.33,;16.29,-4.97,;17.67,-5.65,;15.82,-3.51,;16.71,-2.25,;15.8,-1.01,;14.33,-1.5,;13,-.73,;11.67,-1.5,;11.67,-3.04,;10.34,-3.81,;10.34,-5.35,;9.1,-6.26,;9.57,-7.71,;11.11,-7.73,;12.2,-8.82,;11.58,-6.26,;13,-3.81,;14.35,-3.04,)|

Structure