Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 1B | ||
Ligand | BDBM50473512 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1371 (CHEMBL616444) | ||
IC50 | 9.5±n/a nM | ||
Citation | Jandu, KS; Barrett, V; Brockwell, M; Cambridge, D; Farrant, DR; Foster, C; Giles, H; Glen, RC; Hill, AP; Hobbs, H; Honey, A; Martin, GR; Salmon, J; Smith, D; Woollard, P; Selwood, DL Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem44:681-93 (2001) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 1B | |||
Name: | 5-hydroxytryptamine receptor 1B | ||
Synonyms: | 5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 43579.17 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells | ||
Residue: | 390 | ||
Sequence: |
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BDBM50473512 | |||
n/a | |||
Name | BDBM50473512 | ||
Synonyms: | CHEMBL2368254 | ||
Type | Small organic molecule | ||
Emp. Form. | C18H18N2O | ||
Mol. Mass. | 278.3483 | ||
SMILES | N[C@H]1C[C@@H](C1)c1c[nH]c2ccc(Oc3ccccc3)cc12 |wU:1.0,wD:3.5,(12.4,-12.84,;11.92,-11.37,;10.55,-10.69,;11.23,-9.32,;12.61,-9.99,;10.76,-7.85,;11.65,-6.6,;10.74,-5.35,;9.27,-5.84,;7.94,-5.07,;6.61,-5.86,;6.61,-7.4,;5.27,-8.17,;5.27,-9.71,;6.6,-10.46,;6.61,-12,;5.27,-12.79,;3.93,-12,;3.94,-10.46,;7.94,-8.17,;9.29,-7.38,)| | ||
Structure |