Ki Summary

Reaction Details

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Target

Mitogen-activated protein kinase 13

Ligand

BDBM50473627

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_124318 (CHEMBL732626)

IC50

6.0±n/a nM

Citation

McKenna, JM; Halley, F; Souness, JE; McLay, IM; Pickett, SD; Collis, AJ; Page, K; Ahmed, I An algorithm-directed two-component library synthesized via solid-phase methodology yielding potent and orally bioavailable p38 MAP kinase inhibitors. J Med Chem45:2173-84 (2002) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase 13

Name:

Mitogen-activated protein kinase 13

Synonyms:

Type:

PROTEIN

Mol. Mass.:

42081.17

Organism:

Mus musculus

Description:

ChEMBL_105000

Residue:

366

Sequence:

MSLTRKRGFYKQDINKTAWELPKTYLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPF
QSEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIMGM
EFSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTEMT
GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG
VPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAA
QALAHPFFEPFRDPEEETEAQQPFDDALEHEKLSVDEWKQHIYKEISNFSPIARKDSRRR
SGMKLQ

BDBM50473627

n/a

Name

BDBM50473627

Synonyms:

CHEMBL308203 | RPR-239939

Type

Small organic molecule

Emp. Form.

C26H33FN6O4

Mol. Mass.

512.5764

SMILES

CCCNC(=O)[C@@]1(C)CO[C@@H](OC1)c1nc(c([nH]1)-c1ccnc(NCCCOC)n1)-c1ccc(F)cc1 |wU:10.13,6.6,wD:6.5,(26.03,-17.02,;25.26,-15.68,;23.72,-15.68,;22.96,-14.34,;21.42,-14.34,;20.64,-15.67,;20.66,-13.01,;21.42,-11.67,;19.89,-11.68,;18.37,-11.67,;17.6,-13,;18.37,-14.33,;19.89,-14.33,;16.06,-13,;15.14,-14.24,;13.68,-13.75,;13.68,-12.21,;15.15,-11.75,;12.35,-11.44,;12.35,-9.89,;11.02,-9.12,;9.69,-9.89,;9.69,-11.44,;8.35,-12.21,;7.02,-11.44,;5.68,-12.21,;4.35,-11.44,;3.02,-12.2,;1.69,-11.43,;11.02,-12.21,;12.44,-14.65,;12.59,-16.18,;11.35,-17.08,;9.94,-16.45,;8.6,-17.21,;9.79,-14.91,;11.04,-14.01,)|

Structure