| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1B |
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| Ligand | BDBM50410435 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321066 (CHEMBL872149) |
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| Ki | 4.0±n/a nM |
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| Citation |  Wyman, PA; Marshall, HR; Flynn, ST; King, RJ; Thompson, M; Smith, PW; Hadley, MS; Price, GW; Scott, CM; Dawson, LA Identification of a potent and selective 5-HT1B receptor antagonist. Bioorg Med Chem Lett15:4708-12 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1B |
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| Name: | 5-hydroxytryptamine receptor 1B |
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| Synonyms: | 5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 43579.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells |
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| Residue: | 390 |
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| Sequence: | MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALIT
LATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQV
VCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISI
SLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL
KQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLE
KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL
NSLINPIIYTMSNEDFKQAFHKLIRFKCTS
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| BDBM50410435 |
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| n/a |
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| Name | BDBM50410435 |
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| Synonyms: | CHEMBL191971 | SB-272183 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28ClN5O |
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| Mol. Mass. | 498.019 |
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| SMILES | CN1CCN(CC1)c1cc2N(CCc2cc1Cl)C(=O)Nc1ccc(-c2ccncc2)c2ccccc12 |
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| Structure | 
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