Reaction Details |
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Target | Muscarinic acetylcholine receptor M4 |
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Ligand | BDBM50475680 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_337458 (CHEMBL862222) |
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Ki | 977±n/a nM |
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Citation | Scapecchi, S; Matucci, R; Bellucci, C; Buccioni, M; Dei, S; Guandalini, L; Martelli, C; Manetti, D; Martini, E; Marucci, G; Nesi, M; Romanelli, MN; Teodori, E; Gualtieri, F Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. J Med Chem49:1925-31 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M4 |
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Name: | Muscarinic acetylcholine receptor M4 |
Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 53079.31 |
Organism: | Homo sapiens (Human) |
Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
Residue: | 479 |
Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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BDBM50475680 |
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n/a |
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Name | BDBM50475680 |
Synonyms: | Arecaidine Propargyl Ester |
Type | Small organic molecule |
Emp. Form. | C10H13NO2 |
Mol. Mass. | 179.2157 |
SMILES | CN1CCC=C(C1)C(=O)OCC#C |c:4| |
Structure |
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