| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2C |
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| Ligand | BDBM50475895 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_402581 (CHEMBL906917) |
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| Ki | 158±n/a nM |
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| Citation |  Witty, DR; Bateson, JH; Hervieu, GJ; Jeffrey, P; Johnson, CN; Muir, AI; O'Hanlon, PJ; Stemp, G; Stevens, AJ; Thewlis, KM; Wilson, S; Winborn, KY SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849. Bioorg Med Chem Lett16:4865-71 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2C |
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| Name: | 5-hydroxytryptamine receptor 2C |
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| Synonyms: | 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 51836.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28335 |
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| Residue: | 458 |
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| Sequence: | MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
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| BDBM50475895 |
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| n/a |
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| Name | BDBM50475895 |
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| Synonyms: | CHEMBL385254 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H34N2O3 |
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| Mol. Mass. | 446.5812 |
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| SMILES | COc1cc(NC(=O)c2ccc(cc2)-c2ccccc2)ccc1OCCN(C(C)C)C(C)C |
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| Structure | 
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