Reaction Details |
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Target | Aldo-keto reductase family 1 member B1 [K65Q] |
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Ligand | BDBM16415 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_31634 |
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IC50 | 2700±n/a nM |
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Citation | Sestanj, K; Bellini, F; Fung, S; Abraham, N; Treasurywala, A; Humber, L; Simard-Duquesne, N; Dvornik, D N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor. J Med Chem27:255-6 (1984) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member B1 [K65Q] |
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Name: | Aldo-keto reductase family 1 member B1 [K65Q] |
Synonyms: | AKR1B1 | ALDR_BOVIN | Aldose reductase |
Type: | Protein |
Mol. Mass.: | 35916.27 |
Organism: | Bos taurus (Cattle) |
Description: | P16116[K65Q] |
Residue: | 315 |
Sequence: | AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQA
KLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKD
FFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA
VNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKY
NKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACAL
VSCASHRDYPFHEEF
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BDBM16415 |
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n/a |
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Name | BDBM16415 |
Synonyms: | (1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetic acid | 2-{2,4-dioxo-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(12),5,7,9(13),10-pentaen-3-yl}acetic acid | Alrestatin | CHEMBL63055 | PiG | Spectrum_001449 | Tocris-0485 |
Type | Small organic molecule |
Emp. Form. | C14H9NO4 |
Mol. Mass. | 255.2256 |
SMILES | OC(=O)CN1C(=O)c2cccc3cccc(C1=O)c23 |
Structure |
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