| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50477034 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_449237 (CHEMBL899499) |
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| IC50 | 4.2±n/a nM |
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| Citation |  Chen, YL; Cherry, K; Corman, ML; Ebbinghaus, CF; Gamlath, CB; Liston, D; Martin, BA; Oborski, CE; Sahagan, BG Thiazole-diamides as potent gamma-secretase inhibitors. Bioorg Med Chem Lett17:5518-22 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50477034 |
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| n/a |
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| Name | BDBM50477034 |
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| Synonyms: | CHEMBL238767 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30F2N4O2S |
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| Mol. Mass. | 452.561 |
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| SMILES | CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)NCC(C)C |
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| Structure | 
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