Compile Data Set for Download or QSAR

Found 121 hits with Last Name = 'corman' and Initial = 'ml'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50058163 (Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...) Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)| Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity of the compound against [125I]-Try0-o-Corticotropin-releasing Factor to Corticotropin releasing hormone receptor 1 from ovine				J Med Chem 40: 1749-54 (1997) Article DOI: 10.1021/jm960861b BindingDB Entry DOI: 10.7270/Q2SJ1JQP
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 2 (RAT)	BDBM50058163 (Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...) Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)| Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of binding of [125I]-Tyr0-sauvagine to Corticotropin releasing hormone receptor 2 (CRF2)				J Med Chem 40: 1749-54 (1997) Article DOI: 10.1021/jm960861b BindingDB Entry DOI: 10.7270/Q2SJ1JQP
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477060 (CHEMBL393761) Show SMILES CCC[C@H](NC(=O)CCc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)CCCC(C)(C)O Show InChI InChI=1S/C25H35F2N3O3S/c1-5-7-20(29-22(31)10-9-17-12-18(26)14-19(27)13-17)23(32)30-24-28-15-21(34-24)16(2)8-6-11-25(3,4)33/h12-16,20,33H,5-11H2,1-4H3,(H,29,31)(H,28,30,32)/t16?,20-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477067 (CHEMBL237875) Show SMILES CC[C@H](NC(=O)CCc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)CCCC(C)(C)OC Show InChI InChI=1S/C25H35F2N3O3S/c1-6-20(29-22(31)10-9-17-12-18(26)14-19(27)13-17)23(32)30-24-28-15-21(34-24)16(2)8-7-11-25(3,4)33-5/h12-16,20H,6-11H2,1-5H3,(H,29,31)(H,28,30,32)/t16?,20-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477038 (CHEMBL237850) Show SMILES CC[C@H](NC(=O)CCc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)[C@@H](C)CCCC(C)(C)OC Show InChI InChI=1S/C25H35F2N3O3S/c1-6-20(29-22(31)10-9-17-12-18(26)14-19(27)13-17)23(32)30-24-28-15-21(34-24)16(2)8-7-11-25(3,4)33-5/h12-16,20H,6-11H2,1-5H3,(H,29,31)(H,28,30,32)/t16-,20-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477048 (CHEMBL236597) Show SMILES CCC[C@H](NC(=O)[C@@H](O)C(C)(C)C)C(=O)Nc1ncc(s1)[C@@H](C)CCCC(C)(C)OC Show InChI InChI=1S/C23H41N3O4S/c1-9-11-16(25-20(29)18(27)22(3,4)5)19(28)26-21-24-14-17(31-21)15(2)12-10-13-23(6,7)30-8/h14-16,18,27H,9-13H2,1-8H3,(H,25,29)(H,24,26,28)/t15-,16-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477051 (CHEMBL237666) Show SMILES CCC[C@H](NC(=O)CCc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)CCCC(C)(C)OC Show InChI InChI=1S/C26H37F2N3O3S/c1-6-8-21(30-23(32)11-10-18-13-19(27)15-20(28)14-18)24(33)31-25-29-16-22(35-25)17(2)9-7-12-26(3,4)34-5/h13-17,21H,6-12H2,1-5H3,(H,30,32)(H,29,31,33)/t17?,21-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477046 (CHEMBL236595) Show SMILES COC(C)(C)CCCC(C)c1cnc(NC(=O)[C@H](C)NC(=O)CCc2cc(F)cc(F)c2)s1 Show InChI InChI=1S/C24H33F2N3O3S/c1-15(7-6-10-24(3,4)32-5)20-14-27-23(33-20)29-22(31)16(2)28-21(30)9-8-17-11-18(25)13-19(26)12-17/h11-16H,6-10H2,1-5H3,(H,28,30)(H,27,29,31)/t15?,16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477065 (CHEMBL236592) Show SMILES CCC[C@H](NC(=O)[C@@H](O)C(C)(C)C)C(=O)Nc1ncc(s1)C(C)CCCC(C)(C)O Show InChI InChI=1S/C22H39N3O4S/c1-8-10-15(24-19(28)17(26)21(3,4)5)18(27)25-20-23-13-16(30-20)14(2)11-9-12-22(6,7)29/h13-15,17,26,29H,8-12H2,1-7H3,(H,24,28)(H,23,25,27)/t14?,15-,17+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477040 (CHEMBL237665) Show SMILES CCC[C@H](NC(=O)[C@@H](O)C(C)C)C(=O)Nc1ncc(s1)[C@@H](C)CCCC(C)(C)OC Show InChI InChI=1S/C22H39N3O4S/c1-8-10-16(24-20(28)18(26)14(2)3)19(27)25-21-23-13-17(30-21)15(4)11-9-12-22(5,6)29-7/h13-16,18,26H,8-12H2,1-7H3,(H,24,28)(H,23,25,27)/t15-,16-,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477022 (CHEMBL236594) Show SMILES CCC[C@H](NC(=O)[C@@H](O)C(C)C)C(=O)Nc1ncc(s1)C(C)CCCC(C)(C)OC Show InChI InChI=1S/C22H39N3O4S/c1-8-10-16(24-20(28)18(26)14(2)3)19(27)25-21-23-13-17(30-21)15(4)11-9-12-22(5,6)29-7/h13-16,18,26H,8-12H2,1-7H3,(H,24,28)(H,23,25,27)/t15?,16-,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477037 (CHEMBL237867) Show SMILES CCC[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(CC)CC Show InChI InChI=1S/C21H27F2N3O3S/c1-4-7-16(19(28)26-21-24-11-17(30-21)12(5-2)6-3)25-20(29)18(27)13-8-14(22)10-15(23)9-13/h8-12,16,18,27H,4-7H2,1-3H3,(H,25,29)(H,24,26,28)/t16-,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477021 (CHEMBL236596) Show SMILES CCC[C@H](NC(=O)[C@@H](O)C(C)(C)C)C(=O)Nc1ncc(s1)C(C)CCCC(C)(C)OC Show InChI InChI=1S/C23H41N3O4S/c1-9-11-16(25-20(29)18(27)22(3,4)5)19(28)26-21-24-14-17(31-21)15(2)12-10-13-23(6,7)30-8/h14-16,18,27H,9-13H2,1-8H3,(H,25,29)(H,24,26,28)/t15?,16-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.430	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477061 (CHEMBL393401) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)N[C@@H](C(C)C)C(=O)OC Show InChI InChI=1S/C24H32F2N4O4S/c1-6-7-18(29-20(31)10-15-8-16(25)11-17(26)9-15)22(32)30-24-27-12-19(35-24)14(4)28-21(13(2)3)23(33)34-5/h8-9,11-14,18,21,28H,6-7,10H2,1-5H3,(H,29,31)(H,27,30,32)/t14?,18-,21-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477041 (CHEMBL393397) Show SMILES CCCC(CCC)c1cnc(NC(=O)[C@H](CCC)NC(=O)Cc2cc(F)cc(F)c2)s1 Show InChI InChI=1S/C23H31F2N3O2S/c1-4-7-16(8-5-2)20-14-26-23(31-20)28-22(30)19(9-6-3)27-21(29)12-15-10-17(24)13-18(25)11-15/h10-11,13-14,16,19H,4-9,12H2,1-3H3,(H,27,29)(H,26,28,30)/t19-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477050 (CHEMBL236775) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(O)(CC)CC Show InChI InChI=1S/C21H27F2N3O3S/c1-4-7-16(25-18(27)10-13-8-14(22)11-15(23)9-13)19(28)26-20-24-12-17(30-20)21(29,5-2)6-3/h8-9,11-12,16,29H,4-7,10H2,1-3H3,(H,25,27)(H,24,26,28)/t16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477056 (CHEMBL236773) Show SMILES CCC[C@H](NC(=O)[C@@H](O)C(C)(C)C)C(=O)Nc1ncc(s1)[C@H](C)CCCC(C)(C)OC Show InChI InChI=1S/C23H41N3O4S/c1-9-11-16(25-20(29)18(27)22(3,4)5)19(28)26-21-24-14-17(31-21)15(2)12-10-13-23(6,7)30-8/h14-16,18,27H,9-13H2,1-8H3,(H,25,29)(H,24,26,28)/t15-,16+,18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477050 (CHEMBL236775) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(O)(CC)CC Show InChI InChI=1S/C21H27F2N3O3S/c1-4-7-16(25-18(27)10-13-8-14(22)11-15(23)9-13)19(28)26-20-24-12-17(30-20)21(29,5-2)6-3/h8-9,11-12,16,29H,4-7,10H2,1-3H3,(H,25,27)(H,24,26,28)/t16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477047 (CHEMBL240700) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)NCCC(C)(C)C Show InChI InChI=1S/C24H34F2N4O2S/c1-6-7-19(29-21(31)12-16-10-17(25)13-18(26)11-16)22(32)30-23-28-14-20(33-23)15(2)27-9-8-24(3,4)5/h10-11,13-15,19,27H,6-9,12H2,1-5H3,(H,29,31)(H,28,30,32)/t15?,19-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477069 (CHEMBL240068) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)NCc1ccccc1 Show InChI InChI=1S/C25H28F2N4O2S/c1-3-7-21(30-23(32)12-18-10-19(26)13-20(27)11-18)24(33)31-25-29-15-22(34-25)16(2)28-14-17-8-5-4-6-9-17/h4-6,8-11,13,15-16,21,28H,3,7,12,14H2,1-2H3,(H,30,32)(H,29,31,33)/t16?,21-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477057 (CHEMBL237669) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)CC(C)(C)C Show InChI InChI=1S/C23H31F2N3O2S/c1-6-7-18(27-20(29)10-15-8-16(24)11-17(25)9-15)21(30)28-22-26-13-19(31-22)14(2)12-23(3,4)5/h8-9,11,13-14,18H,6-7,10,12H2,1-5H3,(H,27,29)(H,26,28,30)/t14?,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477027 (CHEMBL392759) Show SMILES CCCCNC(C)c1cnc(NC(=O)[C@H](CCC)NC(=O)Cc2cc(F)cc(F)c2)s1 Show InChI InChI=1S/C22H30F2N4O2S/c1-4-6-8-25-14(3)19-13-26-22(31-19)28-21(30)18(7-5-2)27-20(29)11-15-9-16(23)12-17(24)10-15/h9-10,12-14,18,25H,4-8,11H2,1-3H3,(H,27,29)(H,26,28,30)/t14?,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477052 (CHEMBL240066) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1nc(C)c(s1)C(C)NCCC(C)(C)C Show InChI InChI=1S/C25H36F2N4O2S/c1-7-8-20(30-21(32)13-17-11-18(26)14-19(27)12-17)23(33)31-24-29-16(3)22(34-24)15(2)28-10-9-25(4,5)6/h11-12,14-15,20,28H,7-10,13H2,1-6H3,(H,30,32)(H,29,31,33)/t15?,20-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477068 (CHEMBL236790) Show SMILES CCC[C@H](NC(=O)[C@@H](O)c1ccccc1)C(=O)Nc1ncc(s1)C(O)(CC)CC Show InChI InChI=1S/C21H29N3O4S/c1-4-10-15(23-19(27)17(25)14-11-8-7-9-12-14)18(26)24-20-22-13-16(29-20)21(28,5-2)6-3/h7-9,11-13,15,17,25,28H,4-6,10H2,1-3H3,(H,23,27)(H,22,24,26)/t15-,17-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477042 (CHEMBL236774) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(CC)CC Show InChI InChI=1S/C21H27F2N3O2S/c1-4-7-17(25-19(27)10-13-8-15(22)11-16(23)9-13)20(28)26-21-24-12-18(29-21)14(5-2)6-3/h8-9,11-12,14,17H,4-7,10H2,1-3H3,(H,25,27)(H,24,26,28)/t17-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477055 (CHEMBL241350) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)N1CCOCC1 Show InChI InChI=1S/C22H28F2N4O3S/c1-3-4-18(26-20(29)11-15-9-16(23)12-17(24)10-15)21(30)27-22-25-13-19(32-22)14(2)28-5-7-31-8-6-28/h9-10,12-14,18H,3-8,11H2,1-2H3,(H,26,29)(H,25,27,30)/t14?,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477063 (CHEMBL393756) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)NCCC(C)C Show InChI InChI=1S/C23H32F2N4O2S/c1-5-6-19(28-21(30)11-16-9-17(24)12-18(25)10-16)22(31)29-23-27-13-20(32-23)15(4)26-8-7-14(2)3/h9-10,12-15,19,26H,5-8,11H2,1-4H3,(H,28,30)(H,27,29,31)/t15?,19-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477063 (CHEMBL393756) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)NCCC(C)C Show InChI InChI=1S/C23H32F2N4O2S/c1-5-6-19(28-21(30)11-16-9-17(24)12-18(25)10-16)22(31)29-23-27-13-20(32-23)15(4)26-8-7-14(2)3/h9-10,12-15,19,26H,5-8,11H2,1-4H3,(H,28,30)(H,27,29,31)/t15?,19-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477047 (CHEMBL240700) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)NCCC(C)(C)C Show InChI InChI=1S/C24H34F2N4O2S/c1-6-7-19(29-21(31)12-16-10-17(25)13-18(26)11-16)22(32)30-23-28-14-20(33-23)15(2)27-9-8-24(3,4)5/h10-11,13-15,19,27H,6-9,12H2,1-5H3,(H,29,31)(H,28,30,32)/t15?,19-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477068 (CHEMBL236790) Show SMILES CCC[C@H](NC(=O)[C@@H](O)c1ccccc1)C(=O)Nc1ncc(s1)C(O)(CC)CC Show InChI InChI=1S/C21H29N3O4S/c1-4-10-15(23-19(27)17(25)14-11-8-7-9-12-14)18(26)24-20-22-13-16(29-20)21(28,5-2)6-3/h7-9,11-13,15,17,25,28H,4-6,10H2,1-3H3,(H,23,27)(H,22,24,26)/t15-,17-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477069 (CHEMBL240068) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)NCc1ccccc1 Show InChI InChI=1S/C25H28F2N4O2S/c1-3-7-21(30-23(32)12-18-10-19(26)13-20(27)11-18)24(33)31-25-29-15-22(34-25)16(2)28-14-17-8-5-4-6-9-17/h4-6,8-11,13,15-16,21,28H,3,7,12,14H2,1-2H3,(H,30,32)(H,29,31,33)/t16?,21-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477031 (CHEMBL240276) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1nc(C)c(s1)C(C)NCC(C)C Show InChI InChI=1S/C23H32F2N4O2S/c1-6-7-19(28-20(30)10-16-8-17(24)11-18(25)9-16)22(31)29-23-27-15(5)21(32-23)14(4)26-12-13(2)3/h8-9,11,13-14,19,26H,6-7,10,12H2,1-5H3,(H,28,30)(H,27,29,31)/t14?,19-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477031 (CHEMBL240276) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1nc(C)c(s1)C(C)NCC(C)C Show InChI InChI=1S/C23H32F2N4O2S/c1-6-7-19(28-20(30)10-16-8-17(24)11-18(25)9-16)22(31)29-23-27-15(5)21(32-23)14(4)26-12-13(2)3/h8-9,11,13-14,19,26H,6-7,10,12H2,1-5H3,(H,28,30)(H,27,29,31)/t14?,19-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20971 (2-Arylamino-4-alkyloxypyridine, 13 | 3,6-dimethyl-...) Show SMILES CCC(CC)Oc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C Show InChI InChI=1S/C21H30N2O/c1-8-18(9-2)24-19-12-16(6)22-21(17(19)7)23-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477055 (CHEMBL241350) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)N1CCOCC1 Show InChI InChI=1S/C22H28F2N4O3S/c1-3-4-18(26-20(29)11-15-9-16(23)12-17(24)10-15)21(30)27-22-25-13-19(32-22)14(2)28-5-7-31-8-6-28/h9-10,12-14,18H,3-8,11H2,1-2H3,(H,26,29)(H,25,27,30)/t14?,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477061 (CHEMBL393401) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)N[C@@H](C(C)C)C(=O)OC Show InChI InChI=1S/C24H32F2N4O4S/c1-6-7-18(29-20(31)10-15-8-16(25)11-17(26)9-15)22(32)30-24-27-12-19(35-24)14(4)28-21(13(2)3)23(33)34-5/h8-9,11-14,18,21,28H,6-7,10H2,1-5H3,(H,29,31)(H,27,30,32)/t14?,18-,21-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477034 (CHEMBL238767) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)NCC(C)C Show InChI InChI=1S/C22H30F2N4O2S/c1-5-6-18(27-20(29)9-15-7-16(23)10-17(24)8-15)21(30)28-22-26-12-19(31-22)14(4)25-11-13(2)3/h7-8,10,12-14,18,25H,5-6,9,11H2,1-4H3,(H,27,29)(H,26,28,30)/t14?,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477034 (CHEMBL238767) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)NCC(C)C Show InChI InChI=1S/C22H30F2N4O2S/c1-5-6-18(27-20(29)9-15-7-16(23)10-17(24)8-15)21(30)28-22-26-12-19(31-22)14(4)25-11-13(2)3/h7-8,10,12-14,18,25H,5-6,9,11H2,1-4H3,(H,27,29)(H,26,28,30)/t14?,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477023 (CHEMBL238556) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1nc(C)c(s1)C(C)NCC(F)(F)F Show InChI InChI=1S/C21H25F5N4O2S/c1-4-5-16(29-17(31)8-13-6-14(22)9-15(23)7-13)19(32)30-20-28-12(3)18(33-20)11(2)27-10-21(24,25)26/h6-7,9,11,16,27H,4-5,8,10H2,1-3H3,(H,29,31)(H,28,30,32)/t11?,16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477026 (CHEMBL240699) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1nc(C)c(s1)C(C)NCCC(C)C Show InChI InChI=1S/C24H34F2N4O2S/c1-6-7-20(29-21(31)12-17-10-18(25)13-19(26)11-17)23(32)30-24-28-16(5)22(33-24)15(4)27-9-8-14(2)3/h10-11,13-15,20,27H,6-9,12H2,1-5H3,(H,29,31)(H,28,30,32)/t15?,20-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477026 (CHEMBL240699) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1nc(C)c(s1)C(C)NCCC(C)C Show InChI InChI=1S/C24H34F2N4O2S/c1-6-7-20(29-21(31)12-17-10-18(25)13-19(26)11-17)23(32)30-24-28-16(5)22(33-24)15(4)27-9-8-14(2)3/h10-11,13-15,20,27H,6-9,12H2,1-5H3,(H,29,31)(H,28,30,32)/t15?,20-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20966 (2-Aryloxy-4-alkylaminopyridine, 3a | 3,6-dimethyl-...) Show SMILES CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C Show InChI InChI=1S/C21H30N2O/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477045 (CHEMBL393211) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)C Show InChI InChI=1S/C19H23F2N3O2S/c1-4-5-15(18(26)24-19-22-10-16(27-19)11(2)3)23-17(25)8-12-6-13(20)9-14(21)7-12/h6-7,9-11,15H,4-5,8H2,1-3H3,(H,23,25)(H,22,24,26)/t15-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50058163 (Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...) Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)| Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of binding of 70 pM [125I]-Try0-o-Corticotropin-releasing Factor (CFR) to Corticotropin releasing hormone receptor 1 in Rat brain membrane				J Med Chem 40: 1749-54 (1997) Article DOI: 10.1021/jm960861b BindingDB Entry DOI: 10.7270/Q2SJ1JQP
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20968 (2-(4-bromo-2,6-dimethylphenoxy)-3,6-dimethyl-N-(pe...) Show SMILES CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C Show InChI InChI=1S/C20H27BrN2O/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477022 (CHEMBL236594) Show SMILES CCC[C@H](NC(=O)[C@@H](O)C(C)C)C(=O)Nc1ncc(s1)C(C)CCCC(C)(C)OC Show InChI InChI=1S/C22H39N3O4S/c1-8-10-16(24-20(28)18(26)14(2)3)19(27)25-21-23-13-17(30-21)15(4)11-9-12-22(5,6)29-7/h13-16,18,26H,8-12H2,1-7H3,(H,24,28)(H,23,25,27)/t15?,16-,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477052 (CHEMBL240066) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1nc(C)c(s1)C(C)NCCC(C)(C)C Show InChI InChI=1S/C25H36F2N4O2S/c1-7-8-20(30-21(32)13-17-11-18(26)14-19(27)12-17)23(33)31-24-29-16(3)22(34-24)15(2)28-10-9-25(4,5)6/h11-12,14-15,20,28H,7-10,13H2,1-6H3,(H,30,32)(H,29,31,33)/t15?,20-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477060 (CHEMBL393761) Show SMILES CCC[C@H](NC(=O)CCc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)CCCC(C)(C)O Show InChI InChI=1S/C25H35F2N3O3S/c1-5-7-20(29-22(31)10-9-17-12-18(26)14-19(27)13-17)23(32)30-24-28-15-21(34-24)16(2)8-6-11-25(3,4)33/h12-16,20,33H,5-11H2,1-4H3,(H,29,31)(H,28,30,32)/t16?,20-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477027 (CHEMBL392759) Show SMILES CCCCNC(C)c1cnc(NC(=O)[C@H](CCC)NC(=O)Cc2cc(F)cc(F)c2)s1 Show InChI InChI=1S/C22H30F2N4O2S/c1-4-6-8-25-14(3)19-13-26-22(31-19)28-21(30)18(7-5-2)27-20(29)11-15-9-16(23)12-17(24)10-15/h9-10,12-14,18,25H,4-8,11H2,1-3H3,(H,27,29)(H,26,28,30)/t14?,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50477037 (CHEMBL237867) Show SMILES CCC[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(CC)CC Show InChI InChI=1S/C21H27F2N3O3S/c1-4-7-16(19(28)26-21-24-11-17(30-21)12(5-2)6-3)25-20(29)18(27)13-8-14(22)10-15(23)9-13/h8-12,16,18,27H,4-7H2,1-3H3,(H,25,29)(H,24,26,28)/t16-,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assay				Bioorg Med Chem Lett 17: 5518-22 (2007) Article DOI: 10.1016/j.bmcl.2007.08.035 BindingDB Entry DOI: 10.7270/Q2XG9TX8
					More data for this Ligand-Target Pair

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