| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Presenilin-1 |
|---|
| Ligand | BDBM50477045 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_449238 (CHEMBL899500) |
|---|
| IC50 | 5.1±n/a nM |
|---|
| Citation |  Chen, YL; Cherry, K; Corman, ML; Ebbinghaus, CF; Gamlath, CB; Liston, D; Martin, BA; Oborski, CE; Sahagan, BG Thiazole-diamides as potent gamma-secretase inhibitors. Bioorg Med Chem Lett17:5518-22 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Presenilin-1 |
|---|
| Name: | Presenilin-1 |
|---|
| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 52657.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49768 |
|---|
| Residue: | 467 |
|---|
| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
|
|
|
|---|
| BDBM50477045 |
|---|
| n/a |
|---|
| Name | BDBM50477045 |
|---|
| Synonyms: | CHEMBL393211 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23F2N3O2S |
|---|
| Mol. Mass. | 395.467 |
|---|
| SMILES | CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
