| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase protein |
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| Ligand | BDBM2325 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_450286 (CHEMBL900567) |
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| Ki | 30±n/a nM |
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| Citation |  Mai, A; Artico, M; Rotili, D; Tarantino, D; Clotet-Codina, I; Armand-Ugón, M; Ragno, R; Simeoni, S; Sbardella, G; Nawrozkij, MB; Samuele, A; Maga, G; Esté, JA Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains. J Med Chem50:5412-24 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase protein |
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| Name: | Reverse transcriptase protein |
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| Synonyms: | Reverse Transcriptase | Reverse Transcriptase (A62V) | Reverse Transcriptase (F61A) |
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| Type: | Protein |
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| Mol. Mass.: | 30203.56 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WJQ2 |
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| Residue: | 259 |
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| Sequence: | PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWT
VQPIVLPEKDSWTVNDIQK
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| BDBM2325 |
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| n/a |
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| Name | BDBM2325 |
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| Synonyms: | 2-(cyclopentylsulfanyl)-6-[1-(2,6-difluorophenyl)ethyl]-5-methyl-3,4-dihydropyrimidin-4-one | S-DABO | thio-DABO 3w |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20F2N2OS |
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| Mol. Mass. | 350.426 |
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| SMILES | CC(c1nc(SC2CCCC2)[nH]c(=O)c1C)c1c(F)cccc1F |
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| Structure | 
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