| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Receptor-type tyrosine-protein kinase FLT3 |
|---|
| Ligand | BDBM50479264 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_553941 (CHEMBL962874) |
|---|
| IC50 | 975±n/a nM |
|---|
| Citation |  Aly, AH; Edrada-Ebel, R; Indriani, ID; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Proksch, P; Ebel, R Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. J Nat Prod71:972-80 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Receptor-type tyrosine-protein kinase FLT3 |
|---|
| Name: | Receptor-type tyrosine-protein kinase FLT3 |
|---|
| Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 112888.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P36888 |
|---|
| Residue: | 993 |
|---|
| Sequence: | MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP
EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL
QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD
ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE
CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM
STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE
IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA
ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE
GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD
NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD
LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS
ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE
HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL
NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS
NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK
LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
|
|
|
|---|
| BDBM50479264 |
|---|
| n/a |
|---|
| Name | BDBM50479264 |
|---|
| Synonyms: | Alternariol 5-O-Sulfate | CHEMBL483525 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H10O8S |
|---|
| Mol. Mass. | 338.289 |
|---|
| SMILES | Cc1cc(O)cc2oc(=O)c3c(O)cc(OS(O)(=O)=O)cc3c12 |
|---|
| Structure | 
|
|---|
Search and Browse
