| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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| Ligand | BDBM50244787 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_512164 (CHEMBL968023) |
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| IC50 | 4100±n/a nM |
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| Citation |  Oumata, N; Bettayeb, K; Ferandin, Y; Demange, L; Lopez-Giral, A; Goddard, ML; Myrianthopoulos, V; Mikros, E; Flajolet, M; Greengard, P; Meijer, L; Galons, H Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J Med Chem51:5229-42 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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| Name: | Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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| Synonyms: | Glycogen synthase kinase-3 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 2105817 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | Glycogen synthase kinase 3 beta | Glycogen synthase kinase-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46774.42 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_939732 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTMVATPGQGPDRPQEVSYTDAK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQTNNTASASASNST
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| Component 2 |
| Name: | [Tau protein] kinase |
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| Synonyms: | GSK3A | Glycogen synthase kinase 3 alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51010.29 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_117799 |
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| Residue: | 483 |
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| Sequence: | MSGGAPSGGGPGGSGRARTSSFAEHGGGGGGSGGGPGGSASGPGGGGGGKPSVGAMGGGV
GASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLADTRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPIIYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATGYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAITLCSSLLEYTPSSRLSPLEACAHNFFDELRCPGTQLPNNRPLP
PLFNFSPGELTIQPSLNAILIPPHLRSPAGTASLTSSSQALSETPTGPDWQSTDATTPLT
NSS
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| BDBM50244787 |
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| n/a |
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| Name | BDBM50244787 |
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| Synonyms: | (R)-2-(1-Hydroxybut-2-ylamino)-6-[3-(2-pyridyl)phenylamino]-9-isopropylpurine | CHEMBL215919 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27N7O |
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| Mol. Mass. | 417.5068 |
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| SMILES | CC[C@H](CO)Nc1nc(Nc2cccc(c2)-c2ccccn2)c2ncn(C(C)C)c2n1 |r| |
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| Structure | 
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