| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thymidine phosphorylase |
|---|
| Ligand | BDBM50131078 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_563518 (CHEMBL961805) |
|---|
| IC50 | 19000±n/a nM |
|---|
| Citation |  Khan, KM; Ambreen, N; Hussain, S; Perveen, S; Choudhary, MI Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors. Bioorg Med Chem17:2983-8 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thymidine phosphorylase |
|---|
| Name: | Thymidine phosphorylase |
|---|
| Synonyms: | TYPH_ECOLI | TdRPase | Thymidine Phosphorylase (TP) | deoA | tpp | ttg |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 47198.54 |
|---|
| Organism: | Escherichia coli |
|---|
| Description: | n/a |
|---|
| Residue: | 440 |
|---|
| Sequence: | MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLT
MAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHT
GGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSI
PLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLT
DMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKL
QAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALG
MAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAA
IKLADKAPESTPTVYRRISE
|
|
|
|---|
| BDBM50131078 |
|---|
| n/a |
|---|
| Name | BDBM50131078 |
|---|
| Synonyms: | 3-formylchromones | 4-Oxo-4H-chromene-3-carbaldehyde | CHEMBL86905 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H6O3 |
|---|
| Mol. Mass. | 174.1528 |
|---|
| SMILES | O=Cc1coc2ccccc2c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
