| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylalanine-4-hydroxylase |
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| Ligand | BDBM50028426 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_154856 |
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| Ki | 7000±n/a nM |
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| Citation |  Henrie, RN; Lazarus, RA; Benkovic, SJ Preparation of 2-amino-4(3H)-oxopyrimido[5,4-b] [1,4]thiazines (5-thiapterins) and their evaluation as cofactors for phenylalanine hydroxylase. J Med Chem26:559-63 (1983) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylalanine-4-hydroxylase |
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| Name: | Phenylalanine-4-hydroxylase |
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| Synonyms: | PH4H_RAT | Pah | Phe-4-monooxygenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51817.61 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_154856 |
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| Residue: | 453 |
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| Sequence: | MAAVVLENGVLSRKLSDFGQETSYIEDNSNQNGAISLIFSLKEEVGALAKVLRLFEENDI
NLTHIESRPSRLNKDEYEFFTYLDKRTKPVLGSIIKSLRNDIGATVHELSRDKEKNTVPW
FPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYT
EEEKQTWGTVFRTLKALYKTHACYEHNHIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGF
RLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFA
QFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKEGDSIKAYGAGLLSSFGELQYCLSD
KPKLLPLELEKTACQEYSVTEFQPLYYVAESFSDAKEKVRTFAATIPRPFSVRYDPYTQR
VEVLDNTQQLKILADSINSEVGILCNALQKIKS
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| BDBM50028426 |
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| n/a |
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| Name | BDBM50028426 |
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| Synonyms: | 2-Amino-5-oxo-6-phenyl-5,6,7,8-tetrahydro-3H-5lambda*4*-pyrimido[5,4-b][1,4]thiazin-4-one | CHEMBL346895 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H10N4O2S |
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| Mol. Mass. | 274.298 |
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| SMILES | Nc1nc2NC=C(c3ccccc3)S(=O)c2c(=O)[nH]1 |t:5| |
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| Structure | 
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