| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50480787 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_585784 (CHEMBL1060098) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Nizi, E; Orsale, MV; Crescenzi, B; Pescatore, G; Muraglia, E; Alfieri, A; Gardelli, C; Spieser, SA; Summa, V Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: improving cell based activity by the quaternarization of a chiral center. Bioorg Med Chem Lett19:4617-21 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50480787 |
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| n/a |
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| Name | BDBM50480787 |
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| Synonyms: | CHEMBL549592 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26FN5O4 |
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| Mol. Mass. | 431.4606 |
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| SMILES | CN1CCN(CC1(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C)C(C)=O |
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| Structure | 
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