| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50481378 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_605262 (CHEMBL1069342) |
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| IC50 | 390±n/a nM |
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| Citation |  Stanton, MG; Hubbs, J; Sloman, D; Hamblett, C; Andrade, P; Angagaw, M; Bi, G; Black, RM; Crispino, J; Cruz, JC; Fan, E; Farris, G; Hughes, BL; Kenific, CM; Middleton, RE; Nikov, G; Sajonz, P; Shah, S; Shomer, N; Szewczak, AA; Tanga, F; Tudge, MT; Shearman, M; Munoz, B Fluorinated piperidine acetic acids as gamma-secretase modulators. Bioorg Med Chem Lett20:755-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50481378 |
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| n/a |
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| Name | BDBM50481378 |
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| Synonyms: | CHEMBL595152 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27F8NO2 |
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| Mol. Mass. | 513.4639 |
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| SMILES | CC(C)(C)C#CC(CCC(F)(F)F)N1CCC(F)(F)[C@H](CC(O)=O)[C@H]1c1ccc(cc1)C(F)(F)F |
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| Structure | 
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