| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent L-type calcium channel subunit beta-1 |
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| Ligand | BDBM50481491 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_610290 (CHEMBL1068015) |
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| IC50 | 200±n/a nM |
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| Citation |  Pajouhesh, H; Feng, ZP; Ding, Y; Zhang, L; Pajouhesh, H; Morrison, JL; Belardetti, F; Tringham, E; Simonson, E; Vanderah, TW; Porreca, F; Zamponi, GW; Mitscher, LA; Snutch, TP Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors. Bioorg Med Chem Lett20:1378-83 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent L-type calcium channel subunit beta-1 |
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| Name: | Voltage-dependent L-type calcium channel subunit beta-1 |
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| Synonyms: | CAB1 | CACB1_HUMAN | CACNB1 | CACNLB1 | Calcium channel voltage-dependent subunit beta 1 | Voltage-dependent L-type calcium channel subunit beta-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65714.34 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117730 |
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| Residue: | 598 |
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| Sequence: | MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSA
ESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVP
VQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR
LGSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTEHVPPYDVVPSMRPIILVGPSLK
GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA
EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG
KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP
NPLLNRTMATAALAASPAPVSNLQGPYLASGDQPLERATGEHASMHEYPGELGQPPGLYP
SSHPPGRAGTLRALSRQDTFDADTPGSRNSAYTELGDSCVDMETDPSEGPGLGDPAGGGT
PPARQGSWEDEEEDYEEELTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGRGVYIR
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| BDBM50481491 |
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| n/a |
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| Name | BDBM50481491 |
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| Synonyms: | CHEMBL597957 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H29Cl2N3O |
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| Mol. Mass. | 530.487 |
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| SMILES | Clc1cccc(C(N2CCN(CC2)C(=O)NC(c2ccccc2)c2ccccc2)c2ccccc2)c1Cl |
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| Structure | 
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