| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50481577 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_608111 (CHEMBL1074800) |
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| IC50 | 28840±n/a nM |
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| Citation |  Rivkin, A; Ahearn, SP; Chichetti, SM; Kim, YR; Li, C; Rosenau, A; Kattar, SD; Jung, J; Shah, S; Hughes, BL; Crispino, JL; Middleton, RE; Szewczak, AA; Munoz, B; Shearman, MS Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators. Bioorg Med Chem Lett20:1269-71 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50481577 |
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| n/a |
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| Name | BDBM50481577 |
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| Synonyms: | CHEMBL591596 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H46N6O2 |
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| Mol. Mass. | 546.7466 |
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| SMILES | COc1ccc(cc1)N1CCN(CC1(C)C)c1nc(Nc2cc(ccc2C)C(C)(C)C)cc(OCCN(C)C)n1 |
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| Structure | 
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