| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50483271 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_700226 (CHEMBL1647327) |
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| IC50 | 201±n/a nM |
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| Citation |  Qin, J; Dhondi, P; Huang, X; Mandal, M; Zhao, Z; Pissarnitski, D; Zhou, W; Aslanian, R; Zhu, Z; Greenlee, W; Clader, J; Zhang, L; Cohen-Williams, M; Jones, N; Hyde, L; Palani, A Discovery of fused 5,6-bicyclic heterocycles as ?-secretase modulators. Bioorg Med Chem Lett21:664-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50483271 |
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| n/a |
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| Name | BDBM50483271 |
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| Synonyms: | CHEMBL1643448 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26F3N5O |
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| Mol. Mass. | 481.5127 |
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| SMILES | CCC(N1CCCc2c(n[nH]c12)-c1ccc(c(OC)c1)-n1cnc(C)c1)c1cc(F)c(F)c(F)c1 |
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| Structure | 
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