| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidase |
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| Ligand | BDBM50483327 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_708717 (CHEMBL1667059) |
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| IC50 | 1300±n/a nM |
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| Citation |  Llarrull, LI; Fisher, JF; Mobashery, S Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge. Antimicrob Agents Chemother53:4051-63 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptidase |
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| Name: | Peptidase |
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| Synonyms: | MecA | Pbp2a | Penicillin binding protein 2 prime | Penicillin binding protein 2' | Penicillin binding protein 2a (PBP2a) | Penicillin-binding protein 2 prime | Penicillin-binding protein 2' |
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| Type: | PROTEIN |
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| Mol. Mass.: | 76113.18 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_677175 |
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| Residue: | 668 |
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| Sequence: | MKKIKIVPLILIVVVVGFGIYFYASKDKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEV
EMTERPIKIYNSLGVKDINIQDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKED
GMWKLDWDHSVIIPGMQKDQSIHIENLKSERGKILDRNNVELANTGTAYEIGIVPKNVSK
KDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSDFAKKFHLTTNETES
RNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDAVIGKKGLEKLYDKKLQHEDGYRVT
IVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLAL
VSTPSYDVYPFMYGMSNEEYNKLTEDKKEPLLNKFQITTSPGSTQKILTAMIGLNNKTLD
DKTSYKIDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGSKKFE
KGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILINPVQILSIYSALEN
NGNINAPHLLKDTKNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGT
AELKMKQGETGRQIGWFISYDKDNPNMMMAINVKDVQDKGMASYNAKISGKVYDELYENG
NKKYDIDE
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| BDBM50483327 |
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| n/a |
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| Name | BDBM50483327 |
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| Synonyms: | CEFTOBIPROLE MEDOCARIL |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26N8O11S2 |
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| Mol. Mass. | 690.662 |
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| SMILES | [H][C@]12SCC(\C=C3/CCN([C@@H]4CCN(C4)C(=O)OCc4oc(=O)oc4C)C3=O)=C(N1C(=O)[C@H]2NC(=O)C(=N\O)\c1nsc(N)n1)C(O)=O |r,c:30| |
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| Structure | 
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