| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
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| Ligand | BDBM50028811 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_152416 |
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| IC50 | 195000±n/a nM |
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| Citation |  Vincek, WC; Aldrich, CS; Borchardt, RT; Grunewald, GL Importance of the aromatic ring in adrenergic amines. 5. Nonaromatic analogues of phenylethanolamine as inhibitors of phenylethanolamine N-methyltransferase: role of hydrophobic and steric interactions. J Med Chem24:7-12 (1981) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylethanolamine N-methyltransferase |
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| Name: | Phenylethanolamine N-methyltransferase |
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| Synonyms: | Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase |
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| Type: | Enzyme |
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| Mol. Mass.: | 30916.97 |
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| Organism: | Bos taurus (bovine) |
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| Description: | n/a |
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| Residue: | 283 |
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| Sequence: | MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
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| BDBM50028811 |
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| n/a |
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| Name | BDBM50028811 |
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| Synonyms: | Adamantan-1-yl-trimethylsilanyloxy-acetonitrile | CHEMBL429382 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H25NOSi |
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| Mol. Mass. | 263.4506 |
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| SMILES | C[Si](C)(C)OC(C#N)C12CC3CC(CC(C3)C1)C2 |TLB:15:10:17:16.14.13,15:14:17:9.10.11,THB:13:12:9:16.14.15,13:14:9:17.12.11| |
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| Structure | 
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