| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin beta chain |
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| Ligand | BDBM50483990 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_755967 (CHEMBL1803857) |
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| IC50 | 570±n/a nM |
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| Citation |  Prinz, H; Chamasmani, B; Vogel, K; Böhm, KJ; Aicher, B; Gerlach, M; Günther, EG; Amon, P; Ivanov, I; Müller, K N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem54:4247-63 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin beta chain |
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| Name: | Tubulin beta chain |
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| Synonyms: | Beta-tubulin | TBB_PIG | Tubulin beta chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49840.26 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_105107 |
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| Residue: | 445 |
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| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEGEEDEA
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| BDBM50483990 |
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| n/a |
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| Name | BDBM50483990 |
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| Synonyms: | CHEMBL1801900 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14ClNO3 |
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| Mol. Mass. | 351.783 |
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| SMILES | COc1ccc(cc1)C(=O)N1c2ccccc2Oc2ccc(Cl)cc12 |
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| Structure | 
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