| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50484296 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_772762 (CHEMBL1837501) |
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| IC50 | 16±n/a nM |
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| Citation |  Aubele, DL; Truong, AP; Dressen, DB; Probst, GD; Bowers, S; Mattson, MN; Semko, CM; Sun, M; Garofalo, AW; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Goldbach, E; Quinn, KP; Sauer, JM; Brigham, EF; Wallace, W; Nguyen, L; Bova, MP; Hemphill, SS; Basi, G Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent ?-secretase inhibitors. Bioorg Med Chem Lett21:5791-4 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50484296 |
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| n/a |
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| Name | BDBM50484296 |
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| Synonyms: | CHEMBL1837043 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19F3N4O2S |
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| Mol. Mass. | 448.461 |
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| SMILES | FC(F)(F)c1ccc(cn1)S(=O)(=O)N1C2CC(CC1c1cn[nH]c1C2)c1ccccc1 |TLB:10:13:15.17.16:24.19.23| |
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| Structure | 
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