| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin beta chain |
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| Ligand | BDBM50030765 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_815990 (CHEMBL2026544) |
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| Kd | 1060±n/a nM |
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| Citation |  Yamazaki, Y; Tanaka, K; Nicholson, B; Deyanat-Yazdi, G; Potts, B; Yoshida, T; Oda, A; Kitagawa, T; Orikasa, S; Kiso, Y; Yasui, H; Akamatsu, M; Chinen, T; Usui, T; Shinozaki, Y; Yakushiji, F; Miller, BR; Neuteboom, S; Palladino, M; Kanoh, K; Lloyd, GK; Hayashi, Y Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure. J Med Chem55:1056-71 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin beta chain |
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| Name: | Tubulin beta chain |
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| Synonyms: | Beta-tubulin | TBB_PIG | Tubulin beta chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49840.26 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_105107 |
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| Residue: | 445 |
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| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEGEEDEA
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| BDBM50030765 |
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| n/a |
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| Name | BDBM50030765 |
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| Synonyms: | NPI-2358 | Plinabulin |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N4O2 |
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| Mol. Mass. | 336.3877 |
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| SMILES | CC(C)(C)c1[nH]cnc1\C=c1/[nH]c(=O)\c(=C\c2ccccc2)[nH]c1=O |
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| Structure | 
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