Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPolyphenol oxidase 2
LigandBDBM60579
Substrate/Competitorn/a
Meas. Tech.ChEMBL_827169 (CHEMBL2050453)
Ki 374±n/a nM
Citation Ha, YMPark, YJKim, JAPark, DPark, JYLee, HJLee, JYMoon, HRChung, HY Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors. Eur J Med Chem49:245-52 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polyphenol oxidase 2
Name:Polyphenol oxidase 2
Synonyms:Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:Protein
Mol. Mass.:63923.66
Organism:Agaricus bisporus (Common mushroom)
Description:O42713
Residue:556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM60579
n/a
NameBDBM60579
Synonyms:(5Z)-5-(4-hydroxybenzylidene)thiazolidine-2,4-quinone | (5Z)-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione | (5Z)-5-[(4-hydroxyphenyl)methylidene]thiazolidine-2,4-dione | MLS000680460 | SMR000324608 | cid_1276529
TypeSmall organic molecule
Emp. Form.C10H7NO3S
Mol. Mass.221.232
SMILESOc1ccc(\C=C2/SC(=O)NC2=O)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: