Reaction Details |
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Target | Phenylethanolamine N-methyltransferase |
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Ligand | BDBM50029099 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_152588 (CHEMBL759766) |
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Ki | 59±n/a nM |
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Citation | Bondinell, WE; Chapin, FW; Girard, GR; Kaiser, C; Krog, AJ; Pavloff, AM; Schwartz, MS; Silvestri, JS; Vaidya, PD; Lam, BL; Wellman, GR; Pendleton, RG Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 1. Chloro-substituted 1,2,3,4-tetrahydroisoquinolines. J Med Chem23:506-11 (1980) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Phenylethanolamine N-methyltransferase |
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Name: | Phenylethanolamine N-methyltransferase |
Synonyms: | Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT) |
Type: | Enzyme |
Mol. Mass.: | 30852.66 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 282 |
Sequence: | MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
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BDBM50029099 |
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n/a |
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Name | BDBM50029099 |
Synonyms: | 5,7,8-Trichloro-1,2,3,4-tetrahydro-isoquinoline | CHEMBL149535 |
Type | Small organic molecule |
Emp. Form. | C9H8Cl3N |
Mol. Mass. | 236.526 |
SMILES | Clc1cc(Cl)c2CCNCc2c1Cl |
Structure |
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