| Reaction Details |
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 | Report a problem with these data |
| Target | Trypanothione reductase |
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| Ligand | BDBM50485930 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_878321 (CHEMBL2185949) |
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| Ki | 3400±n/a nM |
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| Citation |  Lizzi, F; Veronesi, G; Belluti, F; Bergamini, C; López-Sánchez, A; Kaiser, M; Brun, R; Krauth-Siegel, RL; Hall, DG; Rivas, L; Bolognesi, ML Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile. J Med Chem55:10490-500 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Trypanothione reductase |
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| Name: | Trypanothione reductase |
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| Synonyms: | N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYBB | Trypanothione Reductase (TryR) |
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| Type: | Homodimer; oxidoreductase |
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| Mol. Mass.: | 53285.53 |
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| Organism: | Trypanosoma brucei brucei |
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| Description: | n/a |
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| Residue: | 492 |
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| Sequence: | MSKIFDLVVIGAGSGGLEAGWNAATLYKKRVAVIDVQTHHGPPHYAALGGTCVNVGCVPK
KLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGL
DFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGVEHCISSNE
AFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTK
QLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVG
VKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHT
RVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHS
DGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYLK
GEKMETLPESSL
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| BDBM50485930 |
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| n/a |
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| Name | BDBM50485930 |
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| Synonyms: | CHEMBL2179000 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27F3N2O5 |
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| Mol. Mass. | 528.5196 |
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| SMILES | OC(=O)C(F)(F)F.NCCCCCNCc1ccc(OC2=CC(=O)c3cc4ccccc4cc3C2=O)cc1 |t:19| |
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| Structure | 
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