| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50407601 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65814 (CHEMBL679716) |
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| IC50 | 29±n/a nM |
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| Citation |  Fukami, T; Nagase, T; Fujita, K; Hayama, T; Niiyama, K; Mase, T; Nakajima, S; Fukuroda, T; Saeki, T; Nishikibe, M Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists. J Med Chem38:4309-24 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_PIG | Endothelin receptor ET-A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48707.29 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_65803 |
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| Residue: | 427 |
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| Sequence: | METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
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| BDBM50407601 |
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| n/a |
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| Name | BDBM50407601 |
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| Synonyms: | CHEMBL137716 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H44N6O9 |
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| Mol. Mass. | 668.7373 |
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| SMILES | COC(=O)n1cc(C[C@@H]2NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H]3CCCN3C(=O)[C@H](CC(O)=O)NC2=O)C(C)C)c2ccccc12 |
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| Structure | 
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