Reaction Details |
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Target | Renin |
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Ligand | BDBM50029580 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_195769 (CHEMBL803434) |
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IC50 | 10±n/a nM |
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Citation | Patel, DV; Rielly-Gauvin, K; Ryono, DE; Free, CA; Rogers, WL; Smith, SA; DeForrest, JM; Oehl, RS; Petrillo, EW alpha-Hydroxy phosphinyl-based inhibitors of human renin. J Med Chem38:4557-69 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50029580 |
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n/a |
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Name | BDBM50029580 |
Synonyms: | CHEMBL344155 | {(1S,2S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-3-cyclohexyl-1-hydroxy-propyl}-phosphonic acid dimethyl ester |
Type | Small organic molecule |
Emp. Form. | C31H52N3O8P |
Mol. Mass. | 625.7336 |
SMILES | COP(=O)(OC)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C |
Structure |
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