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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Substance-P receptor | ||
| Ligand | BDBM50029856 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_205712 (CHEMBL807959) | ||
| IC50 | 93±n/a nM | ||
| Citation |  Swain, CJ; Seward, EM; Cascieri, MA; Fong, TM; Herbert, R; MacIntyre, DE; Merchant, KJ; Owen, SN; Owens, AP; Sabin, V Identification of a series of 3-(benzyloxy)-1-azabicyclo[2.2.2]octane human NK1 antagonists. J Med Chem38:4793-805 (1996) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Substance-P receptor | |||
| Name: | Substance-P receptor | ||
| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 46254.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P25103 | ||
| Residue: | 407 | ||
| Sequence: |
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| BDBM50029856 | |||
| n/a | |||
| Name | BDBM50029856 | ||
| Synonyms: | 2-Benzhydryl-3-(2-fluoro-benzyloxy)-1-aza-bicyclo[2.2.2]octane | CHEMBL145308 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H28FNO | ||
| Mol. Mass. | 401.5157 | ||
| SMILES | Fc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 |(5.08,.68,;6.42,-.09,;7.73,.68,;9.09,-.09,;9.08,-1.63,;7.74,-2.4,;6.41,-1.62,;5.08,-2.39,;5.06,-3.93,;3.77,-4.7,;2.4,-3.96,;1.08,-4.78,;1.13,-6.33,;2.49,-7.06,;1.75,-5.96,;3.16,-5.1,;3.8,-6.24,;5.16,-6.95,;5.15,-8.49,;6.48,-9.26,;6.49,-10.8,;5.15,-11.57,;3.8,-10.8,;3.8,-9.26,;6.49,-6.19,;7.81,-6.95,;9.15,-6.19,;9.15,-4.65,;7.81,-3.87,;6.49,-4.65,)| | ||
| Structure | 
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