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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Substance-P receptor | ||
| Ligand | BDBM50029864 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_205712 (CHEMBL807959) | ||
| IC50 | 110±n/a nM | ||
| Citation |  Swain, CJ; Seward, EM; Cascieri, MA; Fong, TM; Herbert, R; MacIntyre, DE; Merchant, KJ; Owen, SN; Owens, AP; Sabin, V Identification of a series of 3-(benzyloxy)-1-azabicyclo[2.2.2]octane human NK1 antagonists. J Med Chem38:4793-805 (1996) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Substance-P receptor | |||
| Name: | Substance-P receptor | ||
| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 46254.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P25103 | ||
| Residue: | 407 | ||
| Sequence: |
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| BDBM50029864 | |||
| n/a | |||
| Name | BDBM50029864 | ||
| Synonyms: | 2-Benzhydryl-3-benzyloxy-1-aza-bicyclo[2.2.2]octane | CHEMBL144996 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H29NO | ||
| Mol. Mass. | 383.5253 | ||
| SMILES | C(OC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccccc1 |(6.25,-.54,;6.24,-2.08,;4.91,-2.85,;3.58,-2.06,;2.8,-3.39,;3.88,-4.18,;3.58,-5.14,;2.25,-4.39,;2.25,-2.85,;4.91,-4.39,;6.24,-5.16,;6.24,-6.7,;4.9,-7.45,;4.9,-8.99,;6.24,-9.76,;7.57,-8.99,;7.57,-7.45,;7.57,-4.39,;7.57,-2.85,;8.9,-2.08,;10.24,-2.85,;10.24,-4.39,;8.9,-5.16,;7.58,.23,;8.92,-.54,;10.25,.23,;10.25,1.77,;8.91,2.54,;7.59,1.77,)| | ||
| Structure | 
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