| Reaction Details |
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 | Report a problem with these data |
| Target | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
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| Ligand | BDBM50487149 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_908690 (CHEMBL3065755) |
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| Ki | 1200±n/a nM |
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| Citation |  Wang, K; Wang, W; No, JH; Zhang, Y; Zhang, Y; Oldfield, E Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms. J Am Chem Soc132:6719-27 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
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| Name: | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
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| Synonyms: | (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate reductase (IspH) | ISPH_AQUAE | ispH | lytB |
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| Type: | Enzyme |
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| Mol. Mass.: | 32103.05 |
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| Organism: | Aquifex aeolicus |
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| Description: | O67625 |
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| Residue: | 289 |
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| Sequence: | MVDIIIAEHAGFCFGVKRAVKLAEESLKESQGKVYTLGPIIHNPQEVNRLKNLGVFPSQG
EEFKEGDTVIIRSHGIPPEKEEALRKKGLKVIDATCPYVKAVHEAVCQLTREGYFVVLVG
EKNHPEVIGTLGYLRACNGKGIVVETLEDIGEALKHERVGIVAQTTQNEEFFKEVVGEIA
LWVKEVKVINTICNATSLRQESVKKLAPEVDVMIIIGGKNSGNTRRLYYISKELNPNTYH
IETAEELQPEWFRGVKRVGISAGASTPDWIIEQVKSRIQEICEGQLVSS
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| BDBM50487149 |
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| n/a |
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| Name | BDBM50487149 |
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| Synonyms: | PYRIDIN-3-YL-ETHYL-DIPHOSPHATE |
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| Type | Small organic molecule |
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| Emp. Form. | C7H11NO7P2 |
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| Mol. Mass. | 283.1123 |
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| SMILES | OP(O)(=O)OP(O)(=O)OCCc1cccnc1 |
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| Structure | 
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