| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Type-2 angiotensin II receptor |
|---|
| Ligand | BDBM50030720 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_35273 (CHEMBL648578) |
|---|
| IC50 | 5.3±n/a nM |
|---|
| Citation |  Chang, LL; Ashton, WT; Flanagan, KL; Chen, TB; O'Malley, SS; Zingaro, GJ; Kivlighn, SD; Siegl, PK; Lotti, VJ; Chang, RS Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes. J Med Chem38:3741-58 (1995) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Type-2 angiotensin II receptor |
|---|
| Name: | Type-2 angiotensin II receptor |
|---|
| Synonyms: | AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 41201.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Angiotensin II, central 0 0::P50052 |
|---|
| Residue: | 363 |
|---|
| Sequence: | MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFL
VNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMET
FVS
|
|
|
|---|
| BDBM50030720 |
|---|
| n/a |
|---|
| Name | BDBM50030720 |
|---|
| Synonyms: | CHEMBL122158 | N-{3-[4-(3-Fluoro-2'-(N-t-butyloxycarbonyl)-Sulfanamido-biphenyl-4-ylmethyl)-5-oxo-3-propyl-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-benzamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C37H35F4N5O6S |
|---|
| Mol. Mass. | 753.762 |
|---|
| SMILES | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
