| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50031196 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63969 (CHEMBL677437) |
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| Ki | 0.06±n/a nM |
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| Citation |  Edwards, PD; Zottola, MA; Davis, M; Williams, J; Tuthill, PA Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles. J Med Chem38:3972-82 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50031196 |
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| n/a |
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| Name | BDBM50031196 |
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| Synonyms: | 2-[3-Methyl-2-({1-[3-methyl-2-(4-chlorophenyl-sulfonylamino-benzoylamino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-butyryl]-benzooxazole-5-carboxylic acid methyl ester. 3.7H2O.0.7H2O.0.7ACOH | CHEMBL339307 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H41ClN6O10S |
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| Mol. Mass. | 809.284 |
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| SMILES | COC(=O)c1ccc2oc(nc2c1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(NC(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(C)C |
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| Structure | 
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